• Publications
  • Influence
Facilitative glucose transporters.
  • M. Mueckler
  • Biology, Medicine
    European journal of biochemistry
  • 1 February 1994
TLDR
This review summarizes recent advances concerning the structure, function, and regulation of the Glut proteins.
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
Wolfram syndrome (WFS; OMIM 222300) is an autosomal recessive neurodegenerative disorder defined by young-onset non-immune insulin-dependent diabetes mellitus and progressive optic atrophy. Linkage
Sequence and structure of a human glucose transporter.
TLDR
Structural analysis of the purified human erythrocyte glucose transporter by fast atom bombardment mapping and gas phase Edman degradation confirmed the identity of the clone and demonstrated that the HepG2 and ery Throcyte transporters are highly homologous and may be identical.
The SLC2 (GLUT) family of membrane transporters.
TLDR
This review describes the major characteristics of the 14 GLUT family members and concludes that GLUTs 1-5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types.
Glucose transporters in the 21st Century.
  • B. Thorens, M. Mueckler
  • Biology, Medicine
    American journal of physiology. Endocrinology and…
  • 1 February 2010
TLDR
A very brief summary of the known properties of the 14 Glut proteins is provided and some avenues of future investigation in this area are suggested.
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes*
TLDR
It is concluded that mTOR complexed to RICTOR is the Ser-473 kinase in 3T3-L1 adipocytes, and the apparently disparate results reported in these studies are difficult to evaluate, given that different stimuli and cell types were examined.
The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy*
TLDR
It is concluded that HIV protease inhibitors as a class are capable of selectively inhibiting the transport function of Glut4 and that this effect may be responsible for a major iatrogenic complication frequently observed in HIV patients.
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.
The recent identification of several additional members of the family of sugar transport facilitators (gene symbol SLC2A, protein symbol GLUT) has created a heterogeneous and, in part, confusing
GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst.
TLDR
This work describes a previously unidentified member of the mammalian facilitative GLUT superfamily that exhibits approximately 20-25% identity with other murine facilitativeGLUTs and may be necessary for successful blastocyst development, fuel metabolism, and subsequent implantation.
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.
TLDR
Investigation of the molecular mechanism by which transporter activity is altered in cultured rodent fibroblasts transfected with activated myc, ras, or src oncogenes found the predominant mechanism responsible for activation of the transport system is increased expression of the structural gene encoding the glucose transport protein.
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