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Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT
Multi-detector-row CT angiography (CTA) is a new technology that allows for non-invasive investigation of coronary atherosclerosis in patients. The relation between the morphology of atherosclerotic… Expand
Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent.
One of the key challenges in anticancer therapy is the toxicity and poor bioavailability of the anticancer drugs. Nanotechnology can play a pivotal role by delivering drugs in a targeted fashion to… Expand
A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms.
- Monica Cojoc, K. Maebert, M. Muders, A. Dubrovska
- Medicine, Biology
- Seminars in cancer biology
- 1 April 2015
Similar to normal tissue, many tumors have a hierarchical organization where tumorigenic cancer stem cells (CSCs) differentiate into non-tumorigenic progenies. A host of studies have demonstrated… Expand
Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice.
BACKGROUND & AIMS Inherited mutations in the BRCA2 tumor suppressor have been associated with an increased risk of pancreatic cancer. To establish the contribution of Brca2 to pancreatic cancer we… Expand
Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries.
In the present study, we tested the ability of multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI) to identify and retrospectively characterize atherosclerotic lesions… Expand
Prognostic relevance of 20q13 gains in sporadic colorectal cancers: a FISH analysis
- D. E. Aust, M. Muders, +6 authors G. Baretton
- Scandinavian journal of gastroenterology
- 1 January 2004
Background: Amplification of 20q13 is a frequent chromosomal alteration in solid tumors and harbors a number of putative oncogenes (CAS/CSE1‐L, NABC1, or Aurora2). Amplifications on 20q13 have been… Expand
RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation
Prostate cancer mortality is primarily due to failure to cure patients with metastatic disease. In its early stages, prostate cancer growth is enhanced by androgens. As such, the primary therapy for… Expand
High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients
BackgroundThe Wnt inhibitor Dickkopf-1 (DKK-1) has been linked to the progression of malignant bone disease by impairing osteoblast activity. In addition, there is increasing data to suggest direct… Expand
Molecular Markers for Novel Therapeutic Strategies in Pancreatic Endocrine Tumors
- J. A. Gilbert, Laura J. Adhikari, R. Lloyd, T. Halfdanarson, M. Muders, M. Ames
- Biology, Medicine
- 1 April 2013
Objectives Pancreatic endocrine tumors (PETs) share numerous features with gastrointestinal neuroendocrine (carcinoid) tumors. Targets of novel therapeutic strategies previously assessed in carcinoid… Expand
Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer
Background: Hereditary non-polyposis colorectal cancer (HNPCC) is clinically defined by familial clustering of colorectal cancer and other associated tumours. Methods: By thorough molecular and… Expand