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Contributions of anterior cingulate cortex to behaviour.
The cingulate epilepsy syndrome provides important support of experimental animal and human functional imaging studies for the role of anterior cingulates cortex in movement, affect and social behaviours. Expand
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy
This study provides Class I evidence that responsive cortical stimulation is effective in significantly reducing seizure frequency for 12 weeks in adults who have failed 2 or more antiepileptic medication trials, 3 or more seizures per month, and 1 or 2 seizure foci. Expand
Functional MRI measurement of language lateralization in Wada-tested patients.
Results suggest that, in addition to providing a tool for investigating human cognitive processes, fMRI has significant clinical potential as a non-invasive measure of language lateralization. Expand
MRI abnormalities associated with partial status epilepticus
The radiologic characteristics of status epilepticus resemble those of ischemic stroke but can be differentiated based on lesion location and findings on MRA and postcontrast MRI. Expand
Responsive cortical stimulation for the treatment of epilepsy
The NeuroPace RNS System is discussed, an investigational implantable responsive neurostimulator system that is being evaluated in a multicenter, randomized, double-blinded trial to assess the safety and efficacy of responsive stimulation for the treatment of medically refractory epilepsy. Expand
Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial
To demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partialExpand
Changes in brain morphology associated with obstructive sleep apnea.
This preliminary report indicates changes in brain morphology in OSA, in the hippocampus, a key area for cognitive processing, is indicated. Expand
Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy
Lamotrigine monotherapy may be more appropriate than valproate for women in whom reproductive endocrine or metabolic abnormalities are potential concerns, i.e. women with concerns about weight gain, diabetes, hirsutism, polycystic ovary syndrome, menstrual dysfunction or infertility. Expand
Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis.
This is the first study to report global prevalence of obstructive sleep apnoea; with almost 1 billion people affected, and with prevalence exceeding 50% in some countries, effective diagnostic and treatment strategies are needed to minimise the negative health impacts and to maximise cost-effectiveness. Expand
Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine
To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy.