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Platelet glycoprotein VI: its structure and function.
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Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for…
TLDR
Findings suggest that UT-7 is a new leukemic cell line with megakaryocytic features and with the potential to differentiate into cells with more mature megakARYocytic properties in response to phorbol myristate acetate.
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Association of Fyn and Lyn with the Proline-rich Domain of Glycoprotein VI Regulates Intracellular Signaling*
TLDR
It is demonstrated that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI.
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A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion.
TLDR
The results suggest that GPVI functions as a collagen receptor, and the serum from an idiopathic thrombocytopenic purpura patient contains a specific antibody against GPVI.
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Analysis of the Interaction of Platelet Collagen Receptor Glycoprotein VI (GPVI) with Collagen
TLDR
The data indicate that the high affinity binding site for collagen is composed from two chains of GPVI, and suggest that the binding sites for Cvx are different from the collagen-binding sites and do not need to be formed by two GPVI molecules.
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Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.
TLDR
It is demonstrated that human laminin, purified from placenta, also stimulates formation of filopodia and lamellipodia in human and mouse platelets through a pathway that is dependent on alpha6beta1 and the collagen receptor GPVI.
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Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis.
  • M. MoroiN. Aoki
  • Biology, Chemistry
    The Journal of biological chemistry
  • 10 October 1976
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Laminin stimulates spreading of platelets through integrin α6β1–dependent activation of GPVI
TLDR
It is demonstrated that human laminin, purified from placenta, also stimulates formation of filopodia and lamellipodia in human and mouse platelets through a pathway that is dependent on α6β1 and the collagen receptor GPVI.
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Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation.
TLDR
Results provide the first genetic evidence that PI3K p85alpha plays a significant role in platelet function, almost exclusively in the glycoprotein (GP) VI/Fc receptor gamma chain complex-mediated signaling pathway.
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Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.
TLDR
It was calculated that the activity per milligram of plasminogen of the patient was approximately one-half the values of normal subjects, and it was suggested that the molecular abnormality was inherited as an autosomal characteristic, and the family members who had half the normal levels of activity with normal pl asminogen antigen were heterozygotes whereas the one with practically no plAsminogen activity was homozygote.
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