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Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The effects of… Expand
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
In obese patients with type 2 diabetes, insulin delivery to and insulin-dependent glucose uptake by skeletal muscle are delayed and impaired. The mechanisms underlying the delay and impairment are… Expand
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation*
- N. Kubota, Y. Terauchi, +13 authors T. Noda
- Medicine, Biology
- The Journal of Biological Chemistry
- 19 July 2002
The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, and it has been reported to exhibit putative… Expand
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
- N. Kubota, Y. Terauchi, +14 authors T. Noda
- Biology, Medicine
- The Journal of clinical investigation
- 1 October 2004
We previously demonstrated that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory beta cell hyperplasia, and leptin… Expand
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Insulin receptor substrate (Irs) mediates metabolic actions of insulin. Here, we show that hepatic Irs1 and Irs2 function in a distinct manner in the regulation of glucose homeostasis. The PI3K… Expand
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways*
- N. Kubota, Y. Terauchi, +17 authors T. Kadowaki
- Medicine, Biology
- Journal of Biological Chemistry
- 31 March 2006
*Thiazolidinediones have been shown to up-regulate adiponectin expression in white adipose tissue and plasma adiponectin levels, and these up-regulations have been proposed to be a major mechanism of… Expand
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
Hepatic insulin signalling involves insulin receptor substrates (Irs) 1/2, and is normally associated with the inhibition of gluconeogenesis and activation of lipogenesis. In diabetes and obesity,… Expand
Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.
Adiponectin has been proposed to act as an antidiabetic adipokine, suppressing gluconeogenesis and stimulating fatty acid oxidation in the liver and skeletal muscle. Although adiponectin-knockout… Expand
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that, the IL-4/Irs2/Akt pathway is… Expand
Lack of Insulin Receptor Substrate‐2 Causes Progressive Neointima Formation in Response to Vessel Injury
Background Insulin resistance is associated with atherosclerosis, but its mechanism is unknown. It has been reported that insulin receptor substrate (IRS)‐1 deficient (IRS‐1‐/‐) mice showed insulin… Expand