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Thin-layer chromatography, overlay technique and mass spectrometry: a versatile triad advancing glycosphingolipidomics.
TLDR
It is believed that the combinatorial approach using conventional TLC and modern mass spectrometry provides a developmental advance in exploring the glycosphingolipidome of biological material. Expand
Fragmentation of intra-peptide and inter-peptide disulfide bonds of proteolytic peptides by nanoESI collision-induced dissociation
TLDR
Results on the fragmentation of intra and inter-peptide disulfide bonds of proteolytic peptides by nano electrospray ionisation collision-induced dissociation (nanoESI CID) are shown. Expand
Substrate positioning in chitinase A, a processive chito‐biohydrolase from Serratia marcescens
TLDR
The data show that Trp – GlcNAc stacking in the –3 subsite rigidifies the protein backbone supporting the formation of the intermolecular interaction network that is necessary for the recognition and positioning of the N‐acetyl groups before the –1 subsite. Expand
Elucidation of glycoprotein structures by unspecific proteolysis and direct nanoESI mass spectrometric analysis of ZIC-HILIC-enriched glycopeptides.
TLDR
The presented method is a fast, facile, and inexpensive procedure for the elucidation of protein N-glycosylation and the glycopeptides produced by the above proteases contain short peptide backbones thus improving-probably due to their higher hydrophilicity--the ZIC-HILIC-based separation. Expand
Electron Capture Dissociation of O-Glycosylated Peptides: Radical Site-Induced Fragmentation of Glycosidic Bonds
TLDR
The low energy dissociation method electron capture dissociation (ECD) is applied in a 9.4 T Fourier transform ion cyclotron resonance mass spectrometer to the stuctural elucidation of mucin-derived peptides glycosylated with glycans of different core types, showing different fragmentation patterns driven by the stability of the resulting fragments allowing the discrimination of isomeric glycans. Expand
Dystroglycan Binding to α-Neurexin Competes with Neurexophilin-1 and Neuroligin in the Brain*
TLDR
Expression of αDAG and Nxph1 together with alternative splicing in Nrxn1α may prevent or facilitate formation of distinct trans-synaptic N Rxn·Nlgn complexes, revealing an unanticipated way to contribute to the identity of synaptic subpopulations. Expand
The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling.
TLDR
A novel heterozygous missense mutation (K206N) in the CASQ2 gene is identified in a symptomatic family in which one member died of cardiac arrest and may contribute to the increased propensity to trigger spontaneous Ca(2+) transients in CSQ(K 206N)-expressing myocytes. Expand
The Gas-Phase Basicity and Proton Affinity of 1,3,5-Cycloheptatriene—Energetics, Structure and Interconversion of Dihydrotropylium Ions
The hitherto unknown gas-phase basicity and proton affinity of 1,3,5-cycloheptatriene (CHT) have been determined by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. SeveralExpand
Promiscuous Shiga toxin 2e and its intimate relationship to Forssman.
TLDR
These findings provide a basis for further exploring the functional role of the promiscuous receptor repertoire of Stx2e and the exact nature of the mechanisms that underlie different pathological outcomes of StX2e-producing STEC in humans and pigs. Expand
The α2β1 integrin‐specific antagonist rhodocetin is a cruciform, heterotetrameric molecule
TLDR
Rhodocetin provides not only the prototypic molecular structure for heterotetrameric CLPs, but also a lead structure for pharmaceutical α2β1 integrin antagonists.—Eble, J. A., Niland, S., Bracht, T., Mormann, M., Peter‐Katalinic, J., Pohlentz, G., Stetefeld,J. Expand
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