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Antiproliferative constituents in umbelliferae plants. III. Constituents in the root and the ground part of Anthriscus sylvestris Hoffm.
The MeOH extract of the root and the ground part of Anthriscus sylvestris Hoffm. showed a high inhibitory activity against MK-1, HeLa, and B16F10 cell growth in vitro. The activity was found only in
Cytotoxic activity of polyacetylene compounds in Panax ginseng C. A. Meyer.
Findings indicate that these polyacetylene compounds' mode of action is more dose-dependent than time-dependent, and was much stronger against malignant cells than against normal cells.
Structures and antiproliferative activity of saponins from Sechium pittieri and S. talamancense.
Six bisdesmosidic bayogenin saponins were isolated from the fruit and aerial parts of Sechium pittieri and showed moderate antiproliferative activity against MK-1, HeLa and B16F10 cells.
Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica.
The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone
Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum
Panaxynol and falcarindiol were successfully isolated from the root of Heracleum moellendorffii as antiproliferative polyacetylenes.
Antiproliferative constituents in umbelliferae plants. IV. Constituents in the fruits of Anthriscus sylvestris Hoffm.
The constituents in the fruit of Anthriscus sylvestris Hoffm. were investigated, and four lignans [deoxypodophyllotoxin, morelensin, (-)-deoxypodorhizone, and (-)-hinokinin], one phenylpropanoid
Potentiation of cytotoxicity of mitomycin C bt a polyacetylenic alcohol, panaxytriol
Results suggest that synergistic effects of panaxytriol and MMC may be induced by acceleration of the effect of MMC on cellular that the enhanced accumulation in MK-1 cells treated with panaxyTriol can probably be attributed to the decreased fluidity of the cell membrane caused by panaxy triol.
The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol.
The first specific antibody production against panaxynol is demonstrated, which may be a valuable tool for studies of the biological properties of polyacetylenic compounds.