• Publications
  • Influence
The effect of deleterious mutations on neutral molecular variation.
Selection against deleterious alleles maintained by mutation may cause a reduction in the amount of genetic variability at linked neutral sites. This is because a new neutral variant can only remainExpand
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Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming.
Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation.Expand
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INBREEDING DEPRESSION, GENETIC LOAD, AND THE EVOLUTION OF OUTCROSSING RATES IN A MULTILOCUS SYSTEM WITH NO LINKAGE
We studied deterministic models of multilocus systems subject to mutation–selection balance with all loci unlinked, and with multiplicative interactions of the loci affecting fitness, in partiallyExpand
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Bacterial Communities in Women with Bacterial Vaginosis: High Resolution Phylogenetic Analyses Reveal Relationships of Microbiota to Clinical Criteria
Background Bacterial vaginosis (BV) is a common condition that is associated with numerous adverse health outcomes and is characterized by poorly understood changes in the vaginal microbiota. WeExpand
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Genetic loads and estimates of mutation rates in highly inbred plant populations
ESTIMATES of the rate of mutation to mildly deleterious alleles are fundamental to the testing of theories of the maintenance of sexual reproduction1 and recombination2,3. There are, however, fewExpand
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The pattern of neutral molecular variation under the background selection model.
Stochastic simulations of the infinite sites model were used to study the behavior of genetic diversity at a neutral locus in a genomic region without recombination, but subject to selection againstExpand
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Mutation accumulation in finite outbreeding and inbreeding populations
We have carried out an investigation of the effects of various parameters on the accumulation of deleterious mutant alleles in finite diploid populations. Two different processes contribute toExpand
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Recent genetic selection in the ancestral admixture of Puerto Ricans.
Recent studies have used dense markers to examine the human genome in ancestrally homogeneous populations for hallmarks of selection. No genomewide studies have focused on recently admixedExpand
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Transposable element number in mixed mating populations.
  • M. Morgan
  • Biology, Medicine
  • Genetical research
  • 1 June 2001
Theoretical population genetic studies of transposable elements focus almost exclusively on random mating species, whereas many plants reproduce through partial or substantial self-fertilization.Expand
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EVOLUTION OF A SMALL-MUSCLE POLYMORPHISM IN LINES OF HOUSE MICE SELECTED FOR HIGH ACTIVITY LEVELS
Abstract To study the correlated evolution of locomotor behavior and exercise physiology, we conducted an artificial selection experiment. From the outbred Hsd:ICR strain of Mus domesticus, we beganExpand
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