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Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle

Four distinct mechanisms are currently thought to be involved in the vasodilator effect of cyclic nucleotides and their dependent protein kinases: the decrease in cytosolic calcium concentration, the hyperpolarization of the smooth muscle cell membrane potential, the reduction in the sensitivity of the contractile machinery by decreasing the [Ca2+]c sensitivity of myosin light-chain phosphorylation, and the reduction of the sensitive machinery by uncoupling contraction.
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Pharmacist Interventions in the Management of Type 2 Diabetes Mellitus: A Systematic Review of Randomized Controlled Trials.

The findings from this systematic review clearly support the involvement of pharmacists as members of health care teams in the management of patients with type 2 diabetes.
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Predictors of uncontrolled hypertension and antihypertensive medication nonadherence

Poor medication adherence, lack of information about hypertension, and side effects should be considered as possible underlying causes of uncontrolled BP and must be addressed in any intervention aimed to improve BP control.
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Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: Review and meta-analysis.

A literature review and meta-analysis showed that pharmacist interventions can significantly improve medication adherence, SBP, DBP, and BP control in patients with essential hypertension.
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Clinical pharmacists´ interventions in the management of type 2 diabetes mellitus: a systematic review

The findings support and encourage the integration of clinical pharmacists into multidisciplinary teams, underlining their role in improving the management of type 2 diabetes.
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Pharmacist intervention program to enhance hypertension control: a randomised controlled trial

Pharmacist intervention can significantly improve medication adherence and blood pressure control in patients treated with antihypertensive agents, as evaluated in a prospective randomised controlled trial.
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Blood pressure control and antihypertensive pharmacotherapy patterns in a hypertensive population of Eastern Central Region of Portugal

Clinically important blood pressure decreases can be achieved soon after hypertension medical appointment initiation, however, many hypertensive patients prescribed with antihypertensive therapy fail to achieve blood pressure control in clinical practice, this control being worse among patients with diabetes or chronic kidney disease.
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PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.

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Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition

It is demonstrated that cholesterol and testosterone relax rat aorta by inhibiting LTCC, and this effect of testosterone is not mediated by the classic hormone receptor or by potassium channel activation.
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Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice

The possibility that statin therapy may be useful for BP control in hypertensive hypercholesterolemic patients in clinical practice is raised, as it is found that statins have an antihypertensive effect on blood pressure.
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