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CYP703 Is an Ancient Cytochrome P450 in Land Plants Catalyzing in-Chain Hydroxylation of Lauric Acid to Provide Building Blocks for Sporopollenin Synthesis in Pollen[W]
TLDR
Data demonstrate that in-chain hydroxy lauric acids are essential building blocks in sporopollenin synthesis and enable the formation of ester and ether linkages with phenylpropanoid units. Expand
CYP704B1 Is a Long-Chain Fatty Acid ω-Hydroxylase Essential for Sporopollenin Synthesis in Pollen of Arabidopsis1[W][OA]
TLDR
It is shown that different classes of hydroxylated fatty acids serve as essential compounds for sporopollenin formation, and the genetic relationships between CYP704B1, CYP703A2, and another exine gene, MALE STERILITY2, which encodes a fatty acyl reductase, were explored. Expand
CYP98A3 from Arabidopsis thaliana Is a 3′-Hydroxylase of Phenolic Esters, a Missing Link in the Phenylpropanoid Pathway*
TLDR
It is shown that the gene encoding CYP98A3, which was the best possible P450 candidate for a 3-hydroxylase in the Arabidopsis genome, is highly expressed in inflorescence stems and wounded tissues and catalyzes the synthesis of chlorogenic acid and very likely also the 3-Hydroxylation of lignin monomers. Expand
Genome-Wide Analysis of the Arabidopsis Leaf Transcriptome Reveals Interaction of Phosphate and Sugar Metabolism1[W]
TLDR
Interactions between P and Suc reveal two different signaling programs and novel interactions in gene regulation in response to environmental factors. Expand
Metabolon formation and metabolic channeling in the biosynthesis of plant natural products.
TLDR
New experimental approaches document the importance of channeling in the synthesis of isoprenoids, alkaloids, phenylpropanoids, flavonoids and cyanogenic glucosides. Expand
Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome.
TLDR
Results demonstrate that insertion of high-flux pathways directing synthesis and intracellular storage of high amounts of a cyanogenic glucoside or a glucosinolate is achievable in transgenic A. thaliana plants with marginal inadvertent effects on the transcriptome and metabolome. Expand
Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation.
TLDR
Engineered P450 expression is needed for low-cost production of antineoplastic drugs such as taxol or indole alkaloids and offers the possibility to increase the content of nutraceuticals such as phytoestrogens and antioxidants in plants. Expand
Biosynthesis of the Nitrile Glucosides Rhodiocyanoside A and D and the Cyanogenic Glucosides Lotaustralin and Linamarin in Lotus japonicus1
TLDR
Lotus japonicus was shown to contain the two nitrile glucosides rhodiocyanoside A and rhoduocyanOSide D as well as the cyanogenic glucoside linamarin and lotaustralin, which are derived from the amino acid l-Ile, whereas Linamarin is derived from Val. Expand
Functional characterization of two p-coumaroyl ester 3′-hydroxylase genes from coffee tree: evidence of a candidate for chlorogenic acid biosynthesis
TLDR
The expression patterns of both genes on 4-month old C. canephora plants were studied and found higher transcript levels in young and in highly vascularized organs for both genes, suggestingGene expression and HQA content seemed to be correlated in these organs. Expand
Cyanogenic glycosides: a case study for evolution and application of cytochromes P450
TLDR
The use of metabolic engineering using cytochromes P450 involved in biosynthesis of cyanogenic glycosides allows for the generation of acyanogenic cassava plants or cyanogenic Arabidopsis thaliana plants as well as L. japonicus and A. thalian a plants with altered cyanogenic, cyanoalkenyl or glucosinolate profiles. Expand
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