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IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study
Though not significant, IL10 presented a trend towards protection when only studies with pulmonary TB patients were considered, which reinforces the critical importance of IFNG +874T/A as a genetic marker for TB resistance and this information can be used for better design of a TB vaccine.
Role of tumor necrosis factor-alpha and interleukin-10 promoter gene polymorphisms in leprosy.
A relationship exists between TNF-alpha and IL-10 promoter polymorphisms and the development of PB leprosy, and genotyping data indicate that a relationship exists.
Susceptibility to leprosy is associated with PARK2 and PACRG
Variants in the regulatory region shared by PARK2 and PACRG act as common risk factors for leprosy by using a systematic association scan of the chromosomal interval most likely to harbour this leproSy susceptibility locus.
Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for −819C/T in leprosy susceptibility
Data suggest that low levels of IL-10 during the disease outcome can drive patients to a chronic and unprotective response that culminates with leprosy.
Tropical Infectious Diseases
Molecular Determination of Mycobacterium leprae Viability by Use of Real-Time PCR
- A. Martínez, R. Lahiri, Diana J L Williams
- Biology, MedicineJournal of Clinical Microbiology
- 13 May 2009
Two quantitative reverse transcriptase PCR assays were developed and characterized and consistently identified the presence of M. leprae in eight multibacillary leprosy patient biopsy specimens prior to multidrug therapy (MDT) and demonstrated a decline in viability during the course of MDT.
Single nucleotide polymorphisms in candidate genes and dengue severity in children: a case-control, functional and meta-analysis study.
Stepwise replication identifies a low-producing lymphotoxin-α allele as a major risk factor for early-onset leprosy
The linkage disequilibrium mapping of the second linkage peak of the previous genome-wide scan is reported, located close to the HLA complex, which identifies LTA as a major gene associated with early-onset leprosy.
Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility
The chromosomal region 10p13 has been linked to paucibacillary leprosy in two independent studies. The MRC1 gene, encoding the human mannose receptor (MR), is located in the 10p13 region and…
IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians
The results shown here along with a previously reported meta-analysis of tuberculosis studies indicate that the SNP +874T>A plays a role in resistance to mycobacterial diseases.