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Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia
A tight junction-enriched membrane fraction has been used as immunogen to generate a monoclonal antiserum specific for this intercellular junction. Hybridomas were screened for their ability to bothExpand
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Unconventional Myosins in Inner-Ear Sensory Epithelia
To understand how cells differentially use the dozens of myosin isozymes present in each genome, we examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that isExpand
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Myosin-V is a processive actin-based motor
Class-V myosins, one of 15 known classes of actin-based molecular motors, have been implicated in several forms of organelle transport perhaps working with microtubule-based motors such as kinesin,.Expand
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Brain myosin-V is a two-headed unconventional myosin with motor activity
Chicken myosin-V is a member of a recently recognized class of myosins distinct from both the myosins-I and the myosins-II. We report here the purification, electron microscopic visualization, andExpand
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Drosophila singed, a fascin homolog, is required for actin bundle formation during oogenesis and bristle extension
Drosophila singed mutants were named for their gnarled bristle phenotype but severe alleles are also female sterile. Recently, singed protein was shown to have 35% peptide identity with echinodermExpand
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Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.
Myosin VIIa is a newly identified member of the myosin superfamily of actin-based motors. Recently, the myosin VIIa gene was identified as the gene defective in shaker-1, a recessive deafness in miceExpand
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Role of the S. typhimurium actin-binding protein SipA in bacterial internalization.
Entry of the bacterium Salmonella typhimurium into host cells requires membrane ruffling and rearrangement of the actin cytoskeleton. Here, it is shown that the bacterial protein SipA plays aExpand
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Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains
Recent biochemical studies of p190, a calmodulin (CM)-binding protein purified from vertebrate brain, have demonstrated that this protein, purified as a complex with bound CM, shares a number ofExpand
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Compartmentalization of the cell cortex by septins is required for maintenance of cell polarity in yeast.
Formation and maintenance of specialized plasma membrane domains are crucial for many biological processes, such as cell polarization and signaling. During isotropic bud growth, the yeast cellExpand
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Myosin-V stepping kinetics: a molecular model for processivity.
Myosin-V is a molecular motor that moves processively along its actin track. We have used a feedback-enhanced optical trap to examine the stepping kinetics of this movement. By analyzing theExpand
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