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A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after
TLDR
Serological non-response and the serofast state are common syphilis treatment outcomes, highlighting the importance of determining the immunological and clinical significance of persistent nontreponemal antibody titers after therapy. Expand
Aspergillus sinusitis in cancer patients
TLDR
The findings suggest that aspergillus sinusitis in cancer patients is seen in association with prolonged neutropenia and antibiotic therapy, is amenable to therapy, but tends to recur with relapse of malignancy. Expand
The PIG-A Mutation and Absence of Glycosylphosphatidylinositol-Linked Proteins Do Not Confer Resistance to Apoptosis in Paroxysmal Nocturnal Hemoglobinuria
TLDR
The hypothesis that the PIG-A mutation and absence of GPI-linked surface proteins directly confer resistance to apoptosis in PNH is not supported, indicating that other factors must be important in the origin of this phenomenon and the clonal dominance observed in P NH. Expand
Elevated proapoptotic Bax and caspase 3 activation in the NOD.scid model of Sjögren's syndrome.
TLDR
It is demonstrated that salivary gland epithelial cells in NOD and NOD.scid mice overexpress the proapoptotic molecules Bax and caspase 3, which could be the gene responsible for initiation of caspases activation, epithelial cell destruction, and lymphocyte glandular localization in SS. Expand
The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria.
TLDR
The hypothesis that the PIG-A mutation and absence of GPI-linked surface proteins directly confer resistance to apoptosis in PNH is not supported, indicating that other factors must be important in the origin of this phenomenon and the clonal dominance observed in P NH. Expand
Salivary anti-spectrin autoantibodies in Sjögren's syndrome.
TLDR
It is substantiated that anti-spectrin autoantibodies occur naturally in saliva and their role in immune surveillance or pathology is not clear at present. Expand
Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria.
TLDR
Anti-apoptosis gene upregulation may confer resistance to apoptosis in PNH and related disorders, and provide a common compensatory mechanism after bone marrow injury that allows survival and growth of remaining hematopoietic stem cells. Expand
Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease
TLDR
High-throughput expression profiling of serum proteins using mass spectrometry to identify protein expression patterns that can discern between disease states of HTLV-I-infected individuals is the first application of protein profiling to distinguish between two disease states resulting from a single infectious agent. Expand
A randomised, double-blind, placebo-controlled trial of a recombinant version of human α-fetoprotein (MM-093) in patients with active rheumatoid arthritis
TLDR
Evidence of efficacy was observed in the first randomised, controlled trial of MM-093, a recombinant version of human AFP, in patients with RA, suggesting that MM- 093 may have therapeutic potential in RA. Expand
Right-sided endocarditis from Staphylococcus lugdunensis in a patient with tetralogy of Fallot
TLDR
A case of a child with repaired tetralogy of Fallot found to have right-sided infective endocarditis caused by Staphylococcus lugdunensis is reported. Expand
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