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Suppression of CD4+ T Lymphocyte Activation in Vitro and Experimental Encephalomyelitis in Vivo by the Phosphatidyl Inositol 3-Kinase Inhibitor PIK-75
TLDR
PIK-75 is an efficient suppressor of EAE, modulating lymphocyte function and survival, and its effects on immune and autoimmune responses should be studied. Expand
Human leucocyte antigen‐C in B chronic lymphocytic leukaemia
TLDR
The HLA‐Cw*16 allele frequency was found to be significantly increased amongst patients compared with controls in this population of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Expand
T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response
TLDR
PI3K p110α plays a significant role in antigen activation and differentiation of CD4+ and CD8+ T lymphocytes modulating antitumor immunity. Expand
Characteristics of TCR/CD3 complex CD3ɛ chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo
TLDR
Quantitative and qualitative differences in the TCR/CD3 complex are shown, supporting the hyporesponsive phenotype of Tregs concerning TCR/, and these differences might reconcile avidity and flexible threshold models of TReg differentiation and be used to implement therapeutic approaches involving Treg manipulation. Expand
ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.
TLDR
In vivo, therapeutic administration of ETP-46321 significantly inhibited responses to protein antigen as well as collagen-induced arthritis, as measured by antigen-specific antibody responses, secretion of IL-10, IL-17A or IFN-γ, or clinical symptoms. Expand
Complement regulatory protein Crry/p65 costimulation expands natural treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.
TLDR
The results highlight the potential of the complement regulatory protein Crry to costimulate and expand natural Treg cells capable of suppressing disease in an animal model of chronic inflammatory arthritis. Expand
Effects of 3D nanocomposite bioceramic scaffolds on the immune response.
TLDR
The results obtained in the present study with murine immune cell subpopulations support the biocompatibility of the MGHA material and suggest an adequate host tissue response to their scaffolds upon their implantation. Expand
ICOS deficiency hampers the homeostasis, development and function of NK cells
TLDR
The study shows the functional importance of the ICOS/ICOS-L pair in NK cell homeostasis, differentiation and activity and suggests novel therapeutic targets for NK manipulation. Expand
An Immunological Approach to the Biocompatibility of Mesoporous SiO2-CaO Nanospheres
TLDR
It is demonstrated that SiO2-CaO NanoMBGs are both non-toxic and non-inflammagenic for murine lymphoid cells and myeloid DCs despite their efficient intake by the cells. Expand
Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial
TLDR
BNT162b2 given as a second dose in individuals prime vaccinated with ChAdOx1-S induced a robust immune response, with an acceptable and manageable reactogenicity profile. Expand
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