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Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.
TLDR
Hypoxia-elicited MDR1 gene induction and increased P-glycoprotein expression in nontransformed, primary cultures of human microvascular endothelial cells, and analysis of multicellular spheroids subjected to hypoxia revealed increased resistance to doxorubicin are confirmed. Expand
Neutrophil-derived Glutamate Regulates Vascular Endothelial Barrier Function*
TLDR
It is concluded that activated human PMNs release glutamate and that endothelial expression of group I or III mGluRs function to decrease human brain endothelial VASP phosphorylation and barrier function. Expand
Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1.
TLDR
Investigation of whether oxidative stress increases human umbilical vein endothelial cell cytokeratin 1 (CK1) expression and activates the lectin complement pathway and whether MBL binding to endothelial cytokeratins may mediate LCP activation after oxidative stress suggests that MBLbinding to endothelium may Mediate L CP activation after antioxidant stress. Expand
Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue
TLDR
The results suggest MxIF should be broadly applicable to problems in the fields of basic biological research, drug discovery and development, and clinical diagnostics. Expand
Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat.
TLDR
Anti-C5 therapy significantly improved intestinal I/R tissue injury as well as lung injury and increased intestinal TNF-alpha, IL-1alpha, and vascular ICAM-1 expression after I/ R were significantly inhibited by anti-C 5 mAb. Expand
Inhibition of Mannose-Binding Lectin Reduces Postischemic Myocardial Reperfusion Injury
TLDR
The lectin complement pathway is activated after myocardial ischemia-reperfusion and leads to tissue injury. Expand
Murine model of gastrointestinal ischemia associated with complement-dependent injury.
TLDR
A new murine model of gastrointestinal I/R is developed that has complement-dependent local and remote tissue injury and attenuates tissue injury, neutrophil recruitment, and leukocyte adherence molecule and chemokine expression in the mouse. Expand
Posttranscriptional cell cycle-dependent regulation of human FANCC expression.
TLDR
It is concluded that FANCC expression is controlled by posttranscriptional mechanisms that are proteasome dependent and has important implications for understanding the molecular regulation of the multiprotein complex. Expand
Role for complement in mediating intestinal nitric oxide synthase-2 and superoxide dismutase expression.
TLDR
Data indicate that complement may mediate tissue damage during GI/R by increasing intestinal iNOS and decreasing the activity and protein levels of Cu/Zn SOD and Mn SOD, respectively. Expand
Can Digital Pathology Result In Cost Savings? A Financial Projection For Digital Pathology Implementation At A Large Integrated Health Care Organization
TLDR
Improved patient outcome enabled by this technology strengthens the argument supporting adoption of an enterprise-wide digital pathology system (DPS), and the projected 5-year total cost savings for a large academic-based health care organization upon fully implementing a DPS was approximately $18 million. Expand
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