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Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying
TLDR
Patients with ARDS are in a deficient oxidant—anti-oxidant balance that can get a significant benefit if supplemented with NAC, and treatment by NAC increased extracellular total anti-oxIDant power and total thiol molecules and also improved intracellular glutathione and the outcome of the patients.
Randomized trial of the effect of intravenous paracetamol on inflammatory biomarkers and outcome in febrile critically ill adults
TLDR
The results suggest that antipyretic therapy may not be indicated in all ICU patients and allowing fever to take its natural course does not appear to have detrimental effects on critically ill patients with SIRS and may avoid unnecessary expenses.
Mechanisms underlying stress-induced hyperglycemia in critically ill patients
TLDR
An overview of the current insights in hyperglycemia and insulin resistance in critical illnesses is given and strict glycemic control and intensive insulin therapy could improve the survival rate in critically ill patients.
The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial
TLDR
Although curcumin improved some of lipid profile components, it did not show appreciable effect on inflammatory markers in patients with CAD, and more detailed assessment of metabolic effects or anti-inflammatory activities of curcuming need to perform by extensive human study.
A systematic review on pharmacokinetic changes in critically ill patients: role of extracorporeal membrane oxygenation
TLDR
ECMO is extensively used recently for therapy and as a procedure affects pharmacokinetics profile along with other factors in critically ill patients, for optimizing the pharmacodynamic response and outcome of patients, drug regimen should be individualized through therapeutic drug monitoring whenever possible.
The role of magnesium sulfate in the intensive care unit
TLDR
One rationale for the frequent use of MgSO4 in critical care is the high incidence of hypomagnesaemia in intensive care unit (ICU) patients, which has generated a wide application for Mgso4 in ICU.
How does blood glucose control with metformin influence intensive insulin protocols? Evidence for involvement of oxidative stress and inflammatory cytokines
TLDR
Metformin plus insulin appears to lower the incidence of insulin resistance, lower insulin requirement while maintaining blood glucose level control, and consequently lower the occurrence of adverse effects related to high-dose insulin therapy, particularly hypoglycaemia, and also declined nursing workload.
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