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AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
- M. Mojallal, Yujuan Zheng, +16 authors L. Holmgren
- Medicine, Biology
- Nature communications
- 1 August 2014
The establishment and maintenance of apical-basal cell polarity is essential for the functionality of glandular epithelia. Cell polarity is often lost in advanced tumours correlating with acquisition… Expand
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.
The assembly of individual endothelial cells into multicellular tubes is a complex morphogenetic event in vascular development. Extracellular matrix cues and cell-cell junctional communication are… Expand
A new analytical method for calculating seismic displacements in reinforced retaining walls
ABSTRACT: Calculating the seismic displacement of reinforced retaining walls is important for optimal design of these structures. Using the limit analysis theorem, in this study an innovative… Expand
Abstract A12: AmotL2 linking hypoxia to invasion
Hypoxia has been shown to be a bad prognostic marker correlating with metastasis and poor survival. Furthermore, in response to antiangiogenic therapy hypoxic tumor cells become invasive and form… Expand
Getting in and out of shape : relevance for organ formation and cancer
- M. Mojallal
- 11 September 2014
A central question during development is how single cells form functional multi-cellular organ structures. The high reproducibility indicates intricate synchronization of cellular behaviors such as… Expand
An analytycal method for calculating the natural frequency of retaining walls
For calculating the natural frequency of structures such as buildings, chimneys, bridges and silos appropriate analytical formulas exist. However, in the case of retaining walls undergoing the soil… Expand