• Publications
  • Influence
NFκB inhibitors: Strategies from poxviruses
The orchestration of the inflammatory responses to both infection and tissue damage is arguably the key physiological function of NF-κB, and thus interference with the activation of NF-κB representsExpand
  • 92
  • 9
Cowpox Virus Expresses a Novel Ankyrin Repeat NF-κB Inhibitor That Controls Inflammatory Cell Influx into Virus-Infected Tissues and Is Critical for Virus Pathogenesis
ABSTRACT Many pathogenic orthopoxviruses like variola virus, monkeypox virus, and cowpox virus (CPXV), but not vaccinia virus, encode a unique family of ankyrin (ANK) repeat-containing proteins thatExpand
  • 45
  • 6
RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages
The sensing of pathogen infection and subsequent triggering of innate immunity are key to controlling zoonotic infections. Myxoma virus (MV) is a cytoplasmic DNA poxvirus that in nature infects onlyExpand
  • 76
  • 4
  • PDF
Tumor necrosis factor and interferon: cytokines in harmony
Individually, tumor necrosis factor (TNF) and the various interferons frequently display strong antiviral activities. Certain combinations of these cytokines, however, induce a synergisticExpand
  • 51
  • 4
The Addition of Tumor Necrosis Factor plus Beta Interferon Induces a Novel Synergistic Antiviral State against Poxviruses in Primary Human Fibroblasts
ABSTRACT Tumor necrosis factor (TNF) and members of the interferon (IFN) family have been shown to independently inhibit the replication of a variety of viruses. In addition, previous reports haveExpand
  • 68
  • 4
Co-Regulation of NF-κB and Inflammasome-Mediated Inflammatory Responses by Myxoma Virus Pyrin Domain-Containing Protein M013
NF-κB and inflammasomes both play central roles in orchestrating anti-pathogen responses by rapidly inducing a variety of early-response cytokines and chemokines following infection. Myxoma virusExpand
  • 61
  • 3
  • PDF
Poxvirus Proteomics and Virus-Host Protein Interactions
SUMMARY Studies of the functional proteins encoded by the poxvirus genome provide information about the composition of the virus as well as individual virus-virus protein and virus-host proteinExpand
  • 45
  • 3
  • PDF
Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours
Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types ofExpand
  • 9
  • 3
  • PDF
Cytokine determinants of viral tropism
The specificity of a given virus for a cell type, tissue or species — collectively known as viral tropism — is an important factor in determining the outcome of viral infection in any particularExpand
  • 70
  • 2
Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin.
BACKGROUND Intratumoral heterogeneity in glioblastoma multiforme (GBM) poses a significant barrier to therapy in certain subpopulation such as the tumor-initiating cell population, being shown to beExpand
  • 29
  • 2
  • PDF