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Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis—One Species on the Basis of Genetic Evidence
ABSTRACT Bacillus anthracis, Bacillus cereus, andBacillus thuringiensis are members of the Bacillus cereus group of bacteria, demonstrating widely different phenotypes and pathological effects. B.Expand
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Bacterial SLH domain proteins are non‐covalently anchored to the cell surface via a conserved mechanism involving wall polysaccharide pyruvylation
Several bacterial proteins are non‐covalently anchored to the cell surface via an S‐layer homology (SLH) domain. Previous studies have suggested that this cell surface display mechanism involves aExpand
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A collagen‐like surface glycoprotein is a structural component of the Bacillus anthracis exosporium
Bacillus anthracis , the aetiological agent of anthrax, is a Gram‐positive spore‐forming bacterium. The exosporium is the outermost integument surrounding the mature spore. Here, we describe theExpand
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Germination of Bacillus anthracis spores within alveolar macrophages
The fatal character of the infection caused by inhalation of Bacillus anthracis spores results from a complex pathogenic cycle involving the synthesis of toxins by the bacterium. We have shown usingExpand
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The incompatibility between the PlcR‐ and AtxA‐controlled regulons may have selected a nonsense mutation in Bacillus anthracis
Bacillus anthracis, Bacillus thuringiensis and Bacillus cereus are members of the Bacillus cereus group. These bacteria express virulence in diverse ways in mammals and insects. The pathogenicExpand
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Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages.
Lethal factor (LF) is the major virulence factor produced by Bacillus anthracis. LF is sufficient to cause death in laboratory animals and cytolysis of peritoneal macrophages and macrophage cellExpand
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Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.
The lethal factor (LF) produced by toxigenic strains of Bacillus anthracis is a Zn(2+)-endopeptidase that cleaves the mitogen-activated protein kinase kinases (MAPKKs) MEK1, MEK2 and MKK3. UsingExpand
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Polymorphism in the collagen-like region of the Bacillus anthracis BclA protein leads to variation in exosporium filament length.
We recently identified a Bacillus anthracis glycoprotein which is a structural constituent of the exosporium filaments (P. Sylvestre, E. Couture-Tosi, and M. Mock, Mol. Microbiol. 45:169-178, 2002).Expand
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Identification and characterization of a germination operon on the virulence plasmid pXOl of Bacillus anthracis
The spores of Bacillus anthracis, the agent of anthrax disease, germinate within professional phagocytes, such as murine macrophage‐like RAW264.7 cells and alveolar macrophages. We identified aExpand
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Contribution of ExsFA and ExsFB proteins to the localization of BclA on the spore surface and to the stability of the bacillus anthracis exosporium.
Spores of Bacillus anthracis, the etiological agent of anthrax, and the closely related species Bacillus cereus and Bacillus thuringiensis, possess an exosporium, which is the outermost structureExpand
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