• Publications
  • Influence
Fas ligand in human serum
The Fas ligand (FasL), a member of the tumor necrosis factor family, induces apoptosis in Fas–bearing cells. The membrane–bound human FasL was found to be converted to a soluble form (sFasL) by theExpand
  • 729
  • 26
The Scaffolding Adapter Gab2, via Shp-2, Regulates Kit-evoked Mast Cell Proliferation by Activating the Rac/JNK Pathway*
  • M. Yu, Jincai Luo, +6 authors H. Gu
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 29 September 2006
The scaffolding adapter Gab2 mediates cell signaling and responses evoked by various extracellular stimuli including several growth factors. Kit, the receptor for stem cell factor (SCF), plays aExpand
  • 93
  • 10
Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration.
Stem cell factor (SCF) has crucial roles in proliferation, survival, and differentiation of hematopoietic stem cells and mast cells through binding to c-Kit receptor (KIT). Chemotaxis is anotherExpand
  • 114
  • 9
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
The receptor tyrosine kinase Flt3 is expressed and functionally important in early myeloid progenitor cells and in the majority of acute myeloid leukemia (AML) blasts. Internal tandem duplicationsExpand
  • 310
  • 6
  • PDF
Roles for c-Myc in Self-renewal of Hematopoietic Stem Cells*
Notch and HOXB4 have been reported to expand hematopoietic stem cells (HSCs) in vitro. However, their critical effector molecules remain undetermined. We found that the expression of c-myc, cyclinExpand
  • 150
  • 6
Notch Signals Inhibit the Development of Erythroid/Megakaryocytic Cells by Suppressing GATA-1 Activity through the Induction of HES1*
The effects of Notch signals on the erythroid/megakaryocytic differentiation of hematopoietic cells were examined. Activation of Notch signals by the intracellular Notch1 or an estradiol-inducibleExpand
  • 84
  • 4
  • PDF
Enhanced production of osteopontin in multiple myeloma: clinical and pathogenic implications
Summary. In this study, we examined osteopontin (OPN) production in myeloma cells and plasma OPN levels in multiple myeloma (MM) patients. We assessed OPN production in bone marrow cells (BMCs) byExpand
  • 60
  • 4
Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3-Kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells*
BCR/ABL tyrosine kinase generated from the chromosomal translocation t(9;22) causes chronic myelogenous leukemia and acute lymphoblastic leukemia. To examine the roles of BCR/ABL-activated individualExpand
  • 75
  • 3
A survey of viruses infecting yellow summer squash in South Carolina.
A statewide survey of yellow summer squash was conducted to determine the incidence of cucumber mosaic virus (CMV), papaya ringspot yirus W (PRSV-W, formerly watermelon mosaic virus 1), watermelonExpand
  • 34
  • 3
Transformation of large granular lymphocytic leukemia during the course of a reactivated human herpesvirus-6 infection.
A patient with CD3+ large granular lymphocytic (LGL) leukemia developed transformation (TF). The phenotype of the leukemic cells was CD3+, CD4+ and CD8-. The leukemic cell count increased rapidly;Expand
  • 22
  • 2