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Biosensor discovery of thyroxine transport disrupting chemicals.
- G. Marchesini, A. Meimaridou, +6 authors A. Murk
- Chemistry, MedicineToxicology and applied pharmacology
- 1 October 2008
Results show that the hydroxylated metabolites of the ubiquitous PBDEs not only target the T4 transport at the TTR level, but also, and to a great extent, at the TBG level where most of the T 4 in humans is circulating.
Solution Structure of Microtubule-associated Protein Light Chain 3 and Identification of Its Functional Subdomains*
- T. Kouno, M. Mizuguchi, +7 authors K. Kawano
- Biology, MedicineJournal of Biological Chemistry
- 1 July 2005
It is shown that two subdomains of the LC3-I structure have distinct functions, suggesting that MAP-LC3 can act as an adaptor protein between microtubules and autophagosomes.
Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell death.
- Tatsuro Kamijima, Ayaka Ohmura, +9 authors M. Demura
- Chemistry, MedicineBiochemical and biophysical research…
- 7 November 2008
In this study, heat treatment was used to produce complexes from LAs and oleic acid using a simple method, and heat-treated samples apparently showed much stronger activities than those treated at room temperature, with cytotoxicities equal to that of HAMLET.
Structure of the central hub of bacteriophage Mu baseplate determined by X-ray crystallography of gp44.
- Y. Kondou, D. Kitazawa, +5 authors T. Tsukihara
- Biology, MedicineJournal of molecular biology
- 30 September 2005
The crystal structure of gp44 was determined and it was confirmed that gp44 exists as a trimer exhibiting a hub-like structure with an inner diameter of 25A through which DNA can presumably pass during infection.
Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.
- T. Umeda, K. Ono, +6 authors T. Tomiyama
- Chemistry, MedicineBrain : a journal of neurology
- 1 May 2016
Results indicate that rifampicin could be a promising, ready-to-use medicine for the prevention of Alzheimer's disease and other neurodegenerative diseases.
The molten globule state of a chimera of human alpha-lactalbumin and equine lysozyme.
The results indicate that the native-like packing interaction can stabilize the rudimentary intermediate which is stabilized by the non-specific hydrophobic interactions.
Biosensor recognition of thyroid-disrupting chemicals using transport proteins.
- G. Marchesini, E. Meulenberg, W. Haasnoot, M. Mizuguchi, H. Irth
- Chemistry, MedicineAnalytical chemistry
- 10 January 2006
The TPs-based biosensor assays were more sensitive, easier to perform, and faster to perform than the currently used methods such as radioligand binding assays and immunoprecipitation-HPLC.
Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell
The findings suggest that unlike for wild‐type TTR, the ER quality control system may differentially regulate the fate of the TTR variants and their monomeric counterparts.
Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin.
- T. Yokoyama, M. Mizuguchi, +8 authors N. Niimura
- Chemistry, MedicineJournal of structural biology
- 1 February 2012
The neutron model provides insights into the molecular stability of TTR related to the hydrogen-bond network, the pH sensitivity and the CH···O weak hydrogen bond.
Equilibrium and kinetics of the folding of equine lysozyme studied by circular dichroism spectroscopy.
- M. Mizuguchi, M. Arai, Y. Ke, K. Nitta, K. Kuwajima
- Chemistry, MedicineJournal of molecular biology
- 16 October 1998
It is concluded that the present results are best explained by a sequential model of protein folding, in which the molten globule state is an obligatory folding intermediate on the pathway of folding.