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Identification of neuromedin S and its possible role in the mammalian circadian oscillator system
TLDR
These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.
Ghrelin: a multifunctional hormone in non-mammalian vertebrates.
Neuromedin s is a novel anorexigenic hormone.
TLDR
The results suggest that the novel peptide, NMS, may be a potent anorexigenic hormone in the hypothalamus, and that expression of proopiomelanocortin mRNA in the Arc and CRH RNA in the paraventricular nucleus may be involved in NMS action on feeding.
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.
TLDR
Central des-acyl ghrelin may activate orexin-expressing neurons, perhaps functioning in feeding regulation through interactions with a target protein distinct from the GHS-R.
Peripheral interaction of ghrelin with cholecystokinin on feeding regulation.
TLDR
Results indicate that the vagus nerve plays a crucial role in determining peripheral energy balance and the efficiency of ghrelin and CCK signal transduction may depend on the balance of their respective plasma concentration and/or on interactions between GHS-R andCCK-AR.
Maternal ghrelin plays an important role in rat fetal development during pregnancy.
TLDR
Results indicate that maternal ghrelin regulates fetal development during the late stages of pregnancy, and active immunization of mothers against gh Relin decreased fetal body weight during pregnancy.
Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart
TLDR
Evidence is provided that GC-A activates cardiac RGS4, which attenuates G&agr;q and its downstream hypertrophic signaling, and that R GS4 plays important roles inGC-A-mediated inhibition of cardiac hypertrophy.
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