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Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist.
TLDR
It is demonstrated that RNH-6270 is a potent and AT1-selective angiotensin receptor antagonist and that, after oral administration, CS-866 has a long-lasting ang Elliotensin II inhibitory action which is not affected by drug metabolizing enzymes in the liver. Expand
ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk.
TLDR
A synthetic compound is described as a potent and selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells and the mast cell selectivity and therapeutic potential of ER-27319 is demonstrated in the treatment of allergic disease. Expand
Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker.
TLDR
The blood pressure lowering effects of CS-905 was most potent in DOCA-salt hypertensive rats, followed by SHR, RHR and normotensive Rats, in this order. Expand
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism.
TLDR
It is demonstrated that 8-isopentenylnaringenin acts as an estrogen agonist in the uterus as well as in bone in vivo. Expand
Reproduction toxicity studies with pamidronate.
TLDR
In view of the effects of pamidronate on parturition and the fact that it crosses the placenta and binds to fetal bone, use of the drug in pregnancy should be avoided unless there is a life-saving medical need. Expand
Pharmacological profiles of CS-622, a novel angiotensin converting enzyme inhibitor.
TLDR
Elimination of renal excretory function potentiated the action of captopril but not that of CS-622, suggesting that unlike captoprill, only a small portion of CS -622 is excreted through the kidney. Expand
Effects of captopril on urinary excretion of prostaglandins and electrolytes in spontaneously hypertensive rats.
TLDR
The data suggest that captopril increases renal PG only as an acute phase and that the increase of PG at least partly accounts for natriuretic affects of the agent. Expand
Actions of papaverine on intestinal smooth muscle and its inhibition of cyclic AMP and cyclic GMP phosphodiesterases.
TLDR
Papaverine is reported to be a potent cyclic AMP phosphodiesterase inhibitor and the role of cyclic GMP, which often presents physiological and pharmacological properties, is drawn to. Expand
Effects of Long‐Term Blockade of Angiotensin Converting Enzyme with Captopril (SQ 14,225) on Hemodynamics and Circulating Blood Volume in SHR
TLDR
Long-term blockade of angiotensin converting enzyme (ACE) with captopril dilated blood vessels in the whole body, especially in the brain and kidney, and lowered blood pressure without causing plasma expansion or tachycardia. Expand
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