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Phase Separation of an IgG1 Antibody Solution under a Low Ionic Strength Condition
LLPS was induced in M Ab A solution in a low ionic strength condition due to reversible protein self-association mediated mainly by attractive electrostatic interaction among the MAb A molecules in the heavy phase.
Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition.
Effects of phosphate buffer in parenteral drugs on particle formation from glass vials.
It is suggested that a phosphate buffer solution in a borosilicate glass vial has the ability to form particles due to interactions with the Al that is eluted from the glass during storage.
[Interaction of camptothecin derivatives with human plasma proteins in vitro].
The interactions of camptothecin (CPT) and its derivatives (CPT-11 and SN-38) with human plasma proteins (serum albumin (HSA) and alpha 1-acid glycoprotein (alpha 1-AGP)) were studied mainly by means