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Solution Structure of Acidocin B, a Circular Bacteriocin Produced by Lactobacillus acidophilus M46
- J. Z. Acedo, M. V. van Belkum, Christopher T Lohans, R. McKay, M. Miskolzie, J. Vederas
- Biology, Medicine
- Applied and Environmental Microbiology
- 13 February 2015
The nuclear magnetic resonance (NMR) solution structure of acidocin B in sodium dodecyl sulfate micelles was elucidated, revealing that it is composed of four α-helices of similar length that are folded to form a compact, globular bundle with a central pore. Expand
Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity.
- J. Z. Acedo, M. V. van Belkum, Christopher T Lohans, K. Towle, M. Miskolzie, J. Vederas
- Biology, Medicine
- 15 January 2016
In inhibition studies, inhibition studies showed that LnqQ and AucA have different antimicrobial potency against the Gram-positive strains tested, suggesting that sequence disparities play a crucial role in their mechanisms of action. Expand
Solution structures of the linear leaderless bacteriocins enterocin 7A and 7B resemble carnocyclin A, a circular antimicrobial peptide.
The first three-dimensional structures of enterocins 7A and 7B, leaderless bacteriocins recently isolated from Enterococcus faecalis 710C are reported, showing an unexpected resemblance to carnocyclin A, a 60-residue peptide that is cyclized via an amide bond between the C- and N-termini and has a saposin fold. Expand
NMR Conformational Analyses on (des-bromo) Neuropeptide B [1–23] and Neuropeptide W [1–23]: The Importance of α-helices, a Cation-π Interaction and a β-Turn
Abstract The preferred conformations of the orphan G-protein coupled receptor agonists (des-bromo) neuropeptide B [1–23] and neuropeptide W [1–23], referred to as NPB and NPW, have been determined by… Expand
NMR conformational analyses on (des-bromo) neuropeptide B [1-23] and neuropeptide W [1-23]: the importance of alpha-helices, a cation-pi interaction and a beta-turn.
The preferred conformations of the orphan G-protein coupled receptor agonists (des-bromo) neuropeptide B and NPW are determined by (1)H NMR, CD, and molecular modeling and it is postulated that the N-terminus is involved in membrane recognition and receptor binding. Expand
Solution Structures of Phenol-Soluble Modulins α1, α3, and β2, Virulence Factors from Staphylococcus aureus.
- K. Towle, Christopher T Lohans, M. Miskolzie, J. Z. Acedo, M. V. van Belkum, J. Vederas
- Biology, Medicine
- 15 August 2016
Three of these peptide toxins, PSMs α1, α3, and β2, normally produced by Staphylococcus aureus, have been synthesized using solid-supported peptide synthesis (SPPS) or made by heterologous expression in Escherichia coli (PSMβ2). Expand
Identification and three‐dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria
It is reported that CbnX and CbnY comprise a class IIb (two‐component) bacteriocin in Carnobacteria and does not appear to interact directly and likely require a membrane‐bound receptor to facilitate formation of the bacteriOCin complex. Expand
Solution Structures of Phenol-Soluble Modulins alpha 1, alpha 3, and beta 2, Virulence Factors from Staphylococcus aureus.
A 11B and 31P MAS NMR study of the impact of Ca2+ and Sr2+ network modifying cations on the structure of borate and borophosphate glasses
A ruthenium-dihydrogen putative intermediate in ketone hydrogenation.
- R. Hamilton, Carolyn G. Leong, G. Bigam, M. Miskolzie, S. Bergens
- Chemistry, Medicine
- Journal of the American Chemical Society
- 1 March 2005
A 1H NMR study concludes that the dihydrogen ligand in 2' does not protonate 2-PrOH to a catalytically significant extent, and that 2' requires an added base or hydride source to be an active catalyst. Expand