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A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish.
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Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
TLDR
The single-channel conductance properties of these AChR mutants expressed in Xenopus laevis oocytes indicate that three clusters of negatively charged and glutamine residues neighbouring segment M2 of the α-, β-, γ- and δ-subunits, probably forming three anionic rings, are major determinants of the rate of ion transport.
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Diversity Revealed by a Novel Family of Cadherins Expressed in Neurons at a Synaptic Complex
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Molecular diversity of the NMDA receptor channel
TLDR
Findings suggest that the molecular diversity of the ɛ subunit family underlies the functional heterogeneity of the NMDA receptor channel.
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Characterization of Fyn-mediated Tyrosine Phosphorylation Sites on GluRε2 (NR2B) Subunit of theN-Methyl-d-aspartate Receptor*
TLDR
Tyr-1472 phosphorylation of GluRε2 was greatly reduced infyn mutant mice and significantly enhanced after induction of long term potentiation in the hippocampal CA1 region, suggesting that Tyr-1336, Tyr-1252, and Tyr- 1472 in Glu Rε2 were phosphorylated in human embryonic kidney fibroblasts when co-expressed with active Fyn, and its magnitude became larger in murine brain.
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Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum
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Developmental changes in distribution of NMDA receptor channel subunit mRNAs.
TLDR
Findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development, and the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development.
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Impairment of Suckling Response, Trigeminal Neuronal Pattern Formation, and Hippocampal LTD in NMDA Receptor ε2 Subunit Mutant Mice
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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
TLDR
The conductance and gating properties of the two classes of channels suggest that replacement of the γ-subunit by the ε- subunit is responsible for the functional alteration of the receptor during muscle development.
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Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
TLDR
It is shown that targeted disruption of the mouse εl subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses, which supports the notion that the NMda receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning.
View on Nature
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