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Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold
TLDR
Monte Carlo simulations and fMRI studies of human subjects have been used to verify that this approach can improve statistical power by as much as fivefold over techniques that rely solely on adjusting per pixel false positive probabilities.
Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
TLDR
One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy, which may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.
Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
TLDR
It is suggested that the newly identified dorsal nexus plays a critical role in depressive symptomatology, in effect “hot wiring” networks together; it further suggests that reducing increased connectivity of the dorsal nexus presents a potential therapeutic target.
Nonoxidative glucose consumption during focal physiologic neural activity.
TLDR
Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.
Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
Positron emission tomographic studies of the cortical anatomy of single-word processing
The use of positron emission tomography to measure regional changes in average blood flow during processing of individual auditory and visual words provides support for multiple, parallel routes
Brain work and brain imaging.
TLDR
Neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity.
The default mode network and self-referential processes in depression
TLDR
Depression is characterized by both stimulus-induced heightened activity and a failure to normally down-regulate activity broadly within the DMN, and these findings provide a brain network framework within which to consider the pathophysiology of depression.
Positron emission tomography study of voluntary saccadic eye movements and spatial working memory.
TLDR
Findings closely parallel those of single-cell recording studies with behaving monkeys in indicating that FEF, DLPFC, SMA, and posterior parietal cortex perform computational activity for voluntary purposive saccades.
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