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HER2 Expression and PI3K-Akt Pathway Alterations in Gastric Cancer
The anti-HER2 antibody trastuzumab has led to an era of personalized therapy in gastric cancer (GC). As a result, HER2 expression has become a major concern in GC. HER2 overexpression is seen in… Expand
Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours.
- M. Mikami, K. Nosho, +10 authors Y. Shinomura
- Medicine, Biology
- European journal of cancer
- 1 November 2006
Morphologically, early colorectal tumours can be divided into two groups, protruded-type and flat-type. However, little is known about genetic mechanisms of the latter. We investigated mutations of… Expand
Influence of the rheological properties of airway mucus on cough sound generation
- Y. Hashimoto, A. Murata, M. Mikami, S. Nakamura, Eiichi Yamanaka, S. Kudoh
- 1 March 2003
Objectives: There have been several reports regarding the role of airway mucus in cough sound generation, but the properties of the mucus that influence cough sound generation remain unclear. The… Expand
Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer.
- Y. Sukawa, H. Yamamoto, +12 authors Y. Shinomura
- World journal of gastroenterology
- 7 December 2012
AIM To investigate human epidermal growth factor receptor 2 (HER2)-phosphatidylinositol 3-kinase (PI3K)-v-Akt murine thymoma viral oncogene homolog signaling pathway. METHODS We analyzed 231… Expand
Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.
It is now becoming clear that matrix metalloproteinases (MMPs) play a key role in tumor development and growth. MMPs are overexpressed in a variety of premalignant tumor tissues, including colorectal… Expand
Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas
Morphologically, colorectal adenomas can be divided into two groups, protruded-type and flat-type. However, the accurate frequencies of genetic and epigenetic alterations in flat-type colorectal… Expand
Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease
Objectives: The proteolytic enzyme serrapeptase (SER) is widely used in clinical practice in Japan. We investigated the effect of SER on sputum properties and symptoms in patients with chronic… Expand
Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway.
BRAF is an important gene in colorectal cancers (CRCs) that is associated with molecular characterization and resistance to targeted therapy. Although microRNAs (miRNAs) are useful biomarkers of… Expand
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
- K. Nosho, H. Yamamoto, +6 authors Y. Shinomura
- Biology, Medicine
- European journal of cancer
- 1 September 2006
Colorectal carcinogenesis is initiated mainly by aberrant activation of the Wnt signaling pathway, caused by mutation of either APC or beta-catenin (CTNNB1) gene. Poly(ADP-ribose) polymerase-1… Expand
Clinicopathological and Molecular Characteristics of Serrated Lesions in Japanese Elderly Patients
Background: The population in Japan is aging more rapidly than in any other country. However, no studies have determined the characteristics of the large population of elderly patients with… Expand