M. Miettinen

Publications580
h-index118
Citations53,658
Highly Influential Citations2,983
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Diagnosis of gastrointestinal stromal tumors: A consensus approach.
TLDR
Key elements of the consensus are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term "benign" for any GIST, at least at the present time.
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Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Gastrointestinal (GI) stromal tumors (GISTs) are the most common mesenchymal tumors specific to the GI tract, generally defined as KIT (CD117)-positive tumors with a characteristic set of histologic…
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Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
TLDR
GISTs usually occur in older adults and rarely in children in the second decade and are believed to originate from interstitial cells of Cajal or related stem cells; small intestinal tumors behave more aggressively than gastric tumors with similar parameters.
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Gastrointestinal stromal tumors – definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
TLDR
Ligand-independent activation of KIT appears to be a strong candidate for molecular pathogenesis of GISTs, and it may be a target for future treatment for such tumors.
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Gastrointestinal Stromal Tumors of the Stomach: A Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 1765 Cases With Long-term Follow-up
TLDR
Tumor location in fundus or gastroesophageal junction, coagulative necrosis, ulceration, and mucosal invasion were unfavorable factors, whereas tumor location in antrum was favorable (P < 0.001).
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Most Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic Entity: An Analysis of 32 Cases and a Comprehensive Review of the Literature
TLDR
Most cases of mesenchymal tumor-associated OO, both in the present series and in the reported literature, are due to PMTMCT, and improved recognition of their histologic spectrum, including the presence of bone or osteoid-like matrix in otherwise typical cases and the existence of malignant forms, should allow distinction from other meschymal tumors.
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Atypical and Malignant Glomus Tumors: Analysis of 52 Cases, With a Proposal for the Reclassification of Glomus Tumors
TLDR
Using this classification scheme, metastasis was observed in 38% of tumors fulfilling the criteria for malignancy, and metastatic disease was not seen in any specimen classified as symplastic glomus tumor, glomu tumor of uncertain malignant potential, or glomangiomatosis.
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The Morphologic Spectrum of Hibernoma: A Clinicopathologic Study of 170 Cases
TLDR
Hibernoma is a benign tumor found most often in adults and most commonly in the thigh, with several morphologic variants, and should not be confused with atypical lipomas or well-differentiated liposarcoma.
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Gastrointestinal stromal tumors: radiologic features with pathologic correlation.
TLDR
The series described herein was accumulated over 2 years and includes 64 pathologically proved GISTs (28 gastric, 27 small intestinal, six anorectal, one colonic, one esophageal, and one from the small bowel mesentery).
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Gastrointestinal Stromal Tumors of the Jejunum and Ileum: A Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 906 Cases Before Imatinib With Long-term Follow-up
TLDR
Systematic data on prognosis of small intestinal GISTs of various size and mitotic activity categories can be helpful in management and surveillance of patients with these tumors.
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