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Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.
Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation. Expand
Treatment of vitiligo vulgaris with narrow‐band UVB and oral Polypodium leucotomos extract: a randomized double‐blind placebo‐controlled study
Background  The first choice treatment for vitiligo vulgaris is narrow‐band UVB (NB‐UVB), but no satisfactory treatment exists.
Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin.
Oral Polypodium leucotomos (PL) extract is an effective chemophotoprotector against PUVA-induced skin phototoxicity and leads to substantial benefits of skin protection against damaging effects of PUVA as evidenced by histology. Expand
Skin barrier in atopic dermatitis.
This review summarizes current knowledge on the role of the skin barrier in AD with regard to pathogenesis and treatment, on the relationship between skin barrier abnormalities and immune aberrations, and on potential therapies aimed at repair of theskin barrier. Expand
Increased frequencies of IL‐31‐producing T cells are found in chronic atopic dermatitis skin
It is shown here that T cells in chronic AD skin produce IL‐31 and that AD lesions contain increased levels of these IL‐ 31‐producing T cells, suggesting that a substantial part of previously reported increased IL-31 mRNA levels in AD skin is T cell derived and that these cells may be involved in the pathogenesis of AD. Expand
The European treatment of severe atopic eczema in children taskforce (TREAT) survey
There is a paucity of evidence for the use of systemic agents in children with atopic eczema refractory to conventional therapy, resulting in considerable variation in patient management.
Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin
The in vivo levels of inflammatory mediators in chronic atopic dermatitis (AD) skin are not well‐defined due to the lack of a non‐invasive or minimally invasive sampling technique.
Contact sensitization in Dutch children and adolescents with and without atopic dermatitis – a retrospective analysis
Allergic contact dermatitis is known to occur in children with and without atopic dermatitis, but more data are needed on contact sensitization profiles in these two groups.
A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis
A large number of studies investigating biomarkers in people with AD with dark skin types are lacking, and most research has focused on light skin types. Expand
Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation.
It is demonstrated that inhibiting PKC activity in vivo selectively blocks tanning and reduces basal pigmentation in the epidermis and in anagen hair shafts. Expand