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Fenofibrate enhances barrier function of endothelial continuum within the metastatic niche of prostate cancer cells
TLDR
The data provide a mechanistic rationale for extending the clinical use of fenofibrate and for the combination of this well tolerated vasoactive drug with the existing multidrug regimens used in prostate cancer therapy.
Functional links between Snail-1 and Cx43 account for the recruitment of Cx43-positive cells into the invasive front of prostate cancer.
TLDR
It is demonstrated that Cx43 may differentially predispose prostate cancer cells for invasion in a coupling-dependent and coupling-independent manner and the complexity of C x43 functions during the metastatic cascade of prostate cancer is shown.
Synergistic Cytotoxic and Anti-invasive Effects of Mitoxantrone and Triterpene Saponins from Lysimachia ciliata on Human Prostate Cancer Cells.
TLDR
The synergy of proapoptotic activities of the analyzed cocktails is accompanied by their synergistic effects on prostate cancer cell movement and invasiveness, which confirms that the CIL-1/2 fraction might be considered a potent adjuvant for prostate cancer chemotherapy.
Prostaglandin E2 supports growth of chicken embryo intestinal organoids in Matrigel matrix.
TLDR
It is demonstrated that it is possible to use an isolated chicken embryonic intestinal epithelium to create an organoid culture and prostaglandin E2 is as effective as R-spondin 1 and Noggin in promoting sustained growth and survival of epithelial spheroids.
Flavonoid and phenolic acid profile by LC-MS/MS and biological activity of crude extracts from Chenopodium hybridum aerial parts
Abstract Extracts from leaves and stems of Chenopodium hybridum were characterised for the presence and quantity of flavonoids and phenolic acids by LC-ESI-MS/MS. Five flavonoids and eight phenolic
Fibroblast-to-myofibroblast transition in bronchial asthma
TLDR
An accurate understanding and recognition of all factors affecting fibroblast-to-myofibroblast transition might provide an opportunity to discover efficient methods of counteracting this phenomenon.
Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies.
TLDR
The inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations, which illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells.
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