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- Publications
- Influence
Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders.
- M. Metzger, C. Caldwell, A. Barlow, A. Burns, N. Thapar
- Biology, Medicine
- Gastroenterology
- 1 June 2009
BACKGROUND & AIMS
Enteric nervous system stem cells (ENSSCs) provide potential therapeutic tools to replenish absent ganglia in Hirschsprung's disease. Although full-thickness human postnatal gut… Expand
Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells
- A. Appelt-Menzel, Alevtina Cubukova, +7 authors M. Metzger
- Medicine, Biology
- Stem cell reports
- 23 March 2017
Summary In vitro models of the human blood-brain barrier (BBB) are highly desirable for drug development. This study aims to analyze a set of ten different BBB culture models based on primary cells,… Expand
Expansion and differentiation of neural progenitors derived from the human adult enteric nervous system.
- M. Metzger, P. Bareiss, +8 authors L. Just
- Biology, Medicine
- Gastroenterology
- 1 December 2009
BACKGROUND & AIMS
Neural stem and progenitor cells from the enteric nervous system have been proposed for use in cell-based therapies against specific neurogastrointestinal disorders. Recently,… Expand
Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1.
- D. Y. Huang, K. Boini, +7 authors F. Lang
- Chemistry, Medicine
- American journal of physiology. Regulatory…
- 1 April 2006
Serum- and glucocorticoid-inducible kinase (SGK1) is transcriptionally upregulated by mineralocorticoids and activated by insulin. The kinase stimulates the renal epithelial Na(+) channel and may… Expand
Development of an Advanced Primary Human In Vitro Model of the Small Intestine.
- M. Schweinlin, Sabine Wilhelm, +5 authors M. Metzger
- Biology, Medicine
- Tissue engineering. Part C, Methods
- 1 August 2016
Intestinal in vitro models are valuable tools in drug discovery and infection research. Despite several advantages, the standard cell line-based Transwell(®) models based for example on colonic… Expand
In Vivo Transplantation of Neurosphere-Like Bodies Derived from the Human Postnatal and Adult Enteric Nervous System: A Pilot Study
- S. Hetz, A. Acikgoez, +6 authors M. Metzger
- Biology, Medicine
- PloS one
- 3 April 2014
Recent advances in the in vitro characterization of human adult enteric neural progenitor cells have opened new possibilities for cell-based therapies in gastrointestinal motility disorders. However,… Expand
Non-malignant migration of B16 mouse melanoma cells in the neural crest and invasive growth in the eye cup of the chick embryo
- M. Oppitz, C. Busch, G. Schriek, M. Metzger, L. Just, U. Drews
- Biology, Medicine
- Melanoma research
- 1 February 2007
Melanocytes originate from the neural crest. In a previous study, we observed that human SK-Mel 28 human melanoma cells resumed neural crest cell migration after transplantation into the chick embryo… Expand
Three‐dimensional slice cultures from murine fetal gut for investigations of the enteric nervous system
- M. Metzger, P. Bareiss, I. Nikolov, T. Skutella, L. Just
- Biology, Medicine
- Developmental dynamics : an official publication…
- 1 January 2007
Three‐dimensional intestinal cultures offer new possibilities for the examination of growth potential, analysis of time specific gene expression, and spatial cellular arrangement of enteric nervous… Expand
Public Health Response to Aedes aegypti and Ae. albopictus Mosquitoes Invading California, USA.
- C. C. Porse, V. Kramer, +4 authors D. Vugia
- Medicine
- Emerging infectious diseases
- 2015
Aedes aegypti and Ae. albopictus mosquitoes, primary vectors of dengue and chikungunya viruses, were recently detected in California, USA. The threat of potential local transmission of these viruses… Expand
White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.
- A. Burns, A. Goldstein, +27 authors P. Vanden Berghe
- Biology, Medicine
- Developmental biology
- 15 September 2016
Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of… Expand