Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells*
- T. Coll, Elena Eyre, M. Vázquez-Carrera
- BiologyJournal of Biological Chemistry
- 25 April 2008
A model of cellular lipid metabolism in which oleate protects against palmitate-induced inflammation and insulin resistance in skeletal muscle cells by promoting triglyceride accumulation and mitochondrial β-oxidation through PPARα- and protein kinase A-dependent mechanisms is supported.
Substituting Walnuts for Monounsaturated Fat Improves the Serum Lipid Profile of Hypercholesterolemic Men and Women
- Daniel Zambn, J. Sabat, E. Ros
- MedicineAnnals of Internal Medicine
- 4 April 2000
A dietary intervention study in free-living adult men and women with polygenic hypercholesterolemia to compare the effects of a walnut-rich diet with those of a cholesterol-lowering Mediterranean diet on serum lipid levels, lipoprotein levels, and LDL resistance to oxidation is designed.
Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).
Overall, rupatadine combines histamine and PAF antagonist activities in vivo with high potency, the antihistamine properties being similar to or higher than those of loratadines, whereas rup atadine's PAF antagonists effects were near those of WEB-2066.
Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation.
- T. Coll, M. Jové, M. Vázquez-Carrera
- BiologyDiabetes
- 2006
Findings indicate that palmitate reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving MAPK-ERK and NF-kappaB activation.
Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation.
- M. Jové, A. Planavila, R. Sánchez, M. Merlos, J. Laguna, M. Vázquez-Carrera
- Biology, ChemistryEndocrinology
- 2006
The findings suggest that enhanced TNF-alpha expression and GLUT4 down-regulation caused by palmitate are mediated through the PKC activation, confirming that this enzyme may be a target for either the prevention or the treatment of fatty acid-induced insulin resistance.
Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization
- L. Romero, D. Zamanillo, J. Vela
- Medicine, BiologyBritish Journal of Pharmacology
- 1 August 2012
The sigma‐1 (σ1) receptor is a ligand‐regulated molecular chaperone that has been involved in pain, and the demonstration that σ1 receptor antagonists have efficacy in reversing central sensitization‐related pain sensitivity is still missing.
Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells.
- A. Rebollo, N. Roglans, J. Laguna
- Biology, MedicineBiochimica et Biophysica Acta
- 1 April 2014
Sigma 1 receptor: a new therapeutic target for pain.
- D. Zamanillo, L. Romero, M. Merlos, J. Vela
- Biology, MedicineEuropean Journal of Pharmacology
- 15 September 2013
Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis.
- I. Izquierdo, M. Merlos, J. García-Rafanell
- Medicine, BiologyDrugs of Today
- 1 June 2003
Newly published data on its efficacy and safety suggest that this compound may improve the nasal and non-nasal symptoms in comparison to other currently available second generation H1 receptor antihistamines.
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