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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
TLDR
Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders. Expand
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
TLDR
This review discusses major advances in the understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ. Expand
Development of Monocytes, Macrophages, and Dendritic Cells
TLDR
The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice. Expand
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
TLDR
It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells. Expand
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
TLDR
Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state. Expand
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
TLDR
A combination of tissue- and lineage-specific transcription factors form the regulatory networks controlling chromatin specification in tissue-resident macrophages, and the environment is capable of shaping the chromatin landscape of transplanted bone marrow precursors, and even differentiated macrophage can be reprogrammed when transferred into a new microenvironment. Expand
The origin and development of nonlymphoid tissue CD103+ DCs
TLDR
It is shown that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. Expand
Origin of the lamina propria dendritic cell network.
TLDR
It is shown that monocytes gave rise exclusively to CD103(-)CX(3)CR1(+) lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands. Expand
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
TLDR
New developments in the understanding of the biology of LCs and other langerin+ DCs are described and the challenges that remain in identifying the role of different DC subsets in tissue immunity are discussed. Expand
Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
TLDR
It is shown that common lymphoid and common myeloid progenitors, as well as steady state DCs in thymus, spleen, and epidermis, express Flt3, and it is demonstrated that FlT3L can drive DC development along both the lymphoids and myeloids developmental pathways from Flt 3+ progenitor cells and their progeny DCs. Expand
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