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Genetic studies of body mass index yield new insights for obesity biology
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Defining the role of common variation in the genomic and biological architecture of adult human height
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Maternal age and fetal loss: population based register linkage study
- A. Andersen, J. Wohlfahrt, P. Christens, J. Olsen, M. Melbye
- MedicineBMJ : British Medical Journal
- 24 June 2000
Fetal loss is high in women in their late 30s or older, irrespective of reproductive history, and should be taken into consideration in pregnancy planning and counselling.
Genome partitioning of genetic variation for complex traits using common SNPs
The results provide further evidence that a substantial proportion of heritability is captured by common SNPs, that height, BMI and QTi are highly polygenic traits, and that the additive variation explained by a part of the genome is approximately proportional to the total length of DNA contained within genes therein.
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Replication studies from several populations showed confirming evidence, with families of European ancestry giving strong evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4, and expression studies support a role for MAFBs in palatal development.
The Danish National Birth Cohort - its background, structure and aim
The Danish National Birth Cohort (Better health for mother and child) was established, a large cohort of pregnant women with long-term follow-up of the offspring was the obvious choice because many of the exposures of interest cannot be reconstructed with sufficient validity back in time.
Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype.
- K. Smedby, H. Hjalgrim, H. Adami
- Medicine, BiologyJournal of the National Cancer Institute
- 4 January 2006
These NHL subtypes develop during postantigen exposure stages of lymphocyte differentiation, consistent with a role of antigenic drive in autoimmunity-related lymphomagenesis, suggest that the associations may not be general but rather mediated through specific NHL subtype.
A population-based study of measles, mumps, and rubella vaccination and autism.
This study provides strong evidence against the hypothesis that MMR vaccination causes autism in children born in Denmark from January 1991 through December 1998.
Effects of family history and place and season of birth on the risk of schizophrenia.
- P. Mortensen, C. Pedersen, M. Melbye
- Medicine, PsychologyThe New England journal of medicine
- 25 February 1999
A population-based cohort of 1.75 million persons whose mothers were Danish women born between 1935 and 1978 identified 2669 cases of schizophrenia among cohort members and additional cases among their parents, indicating that the place and season of birth account for many more cases on a population basis.
Recurrence of Congenital Heart Defects in Families
Specific CHDs showed highly variable but strong familial clustering in first-degree relatives, ranging from 3-fold to 80-fold compared with the population prevalence, whereas the crossover risks between dissimilar cases of CHD were weaker.