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Rewiring of Genetic Networks in Response to DNA Damage
DNA Damage Pathways Revealed Despite the dynamic nature of cellular responses, the genetic networks that govern these responses have been mapped primarily as static snapshots. Bandyopadhyay et al.Expand
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Functional Organization of the S. cerevisiae Phosphorylation Network
Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistaticExpand
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Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer.
Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid malignancies. Here, we determined the single-cell transcriptomic landscape of liver cancerExpand
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Malaria parasite‐infected erythrocytes inhibit glucose utilization in uninfected red cells
The erythrocytic stages of the malaria parasite depend on anaerobic glycolysis for energy. Using [2‐13C]glucose and nuclear magnetic resonance, the glucose utilization rate and 2,3‐diphosphoglycerateExpand
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Protective Properties and Surface Localization of Plasmodium falciparum Enolase
ABSTRACT The enolase protein of the human malarial parasite Plasmodium falciparum has recently been characterized. Apart from its glycolytic function, enolase has also been shown to possess antigenicExpand
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Glycolysis in Plasmodium falciparum results in modulation of host enzyme activities.
BACKGROUND & OBJECTIVES Plasmodium falciparum, the causative agent of the most serious form of malaria, infects about 5-10% of the world human population per year. It is well established that theExpand
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The P Domain of the P0 Protein of Plasmodium falciparum Protects against Challenge with Malaria Parasites
ABSTRACT Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domainExpand
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The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok
Summary Memory CD4+ T cells mediate long‐term immunity, and their generation is a key objective of vaccination strategies. However, the transcriptional circuitry controlling the emergence of memoryExpand
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Plant-like phosphofructokinase from Plasmodium falciparum belongs to a novel class of ATP-dependent enzymes.
Malaria parasite-infected erythrocytes exhibit enhanced glucose utilisation and 6-phospho-1-fructokinase (PFK) is a key enzyme in glycolysis. Here we present the characterisation of PFK from theExpand
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Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization.
Nuclear DNA in the male gamete of sexually reproducing animals is organized as sperm chromatin compacted primarily by sperm-specific protamines. Fertilization leads to sperm chromatin remodeling,Expand
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