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Annexin II and bleeding in acute promyelocytic leukemia.
TLDR
Abnormally high levels of expression of annexin II on APL cells increase the production of plasmin, a fibrinolytic protein. Expand
Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist.
TLDR
Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 microg, and has the ocular hypotensive efficacy of PGF2alpha isopropyl ester but with less severe ocular side effects. Expand
Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension.
TLDR
This study identified no statistically significant evidence for a link between MYOC mutations and steroid-induced ocular hypertension. Expand
Existence and role of endogenous ocular melatonin.
TLDR
The results suggest that melatonergic mechanisms in the eye could be responsible for the diurnal rhythm in IOP, and the synthesis and diurnalythm of this melatonin are independent of the pineal gland. Expand
Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes.
TLDR
Data indicate that cabergoline's most prominent agonist activity involves activation of 5HT(2),5HT(1A), and D(2/3) receptors, and Cabergoline was an efficacious IOP-lowering agent in normotensive Brown Norway rats. Expand
Ocular hypotensive and aqueous outflow-enhancing effects of AL-3037A (sodium ferri ethylenediaminetetraacetate).
TLDR
In the four study models across three animal species, AL-3037A was demonstrated to be an efficacious ocular hypotensive compound whose effect is most likely mediated by augmentation of the aqueous outflow. Expand
Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.
TLDR
Clinical studies show that travoprost 0.004% (isopropyl ester) provided intraocular pressure control superior to timolol 0.5% when used as monotherapy in patients with open-angle glaucoma or ocular hypertension, and AL-6598 0.01% provided a sustained intraocular Pressure reduction with q.i.d. application. Expand
Evaluation of the Ocular Hypotensive Response of Serotonin 5-HT1A and 5-HT2 Receptor Ligands in Conscious Ocular Hypertensive Cynomolgus Monkeys
TLDR
Compounds that function as efficient agonists at 5-HT2 receptors should be considered as potential agents for the control of intraocular pressure in the treatment of ocular hypertension and glaucoma in humans. Expand
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
TLDR
1-((S)-2-Aminopropyl)-1H-indazol-6-ol (9) appears to be an excellent 5-HT(2) receptor agonist for conducting further studies directed toward a clinical proof-of-concept study for this class of ocular hypotensive agents. Expand
Aqueous humor dynamics in monkeys with laser-induced glaucoma.
TLDR
The increased IOP in monkeys with laser-induced glaucoma was caused by a sustained reduction in outflow facility, and the uveoscleral outflow increase was not enough to prevent the rise in IOP. Expand
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