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Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III
A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication. The introduction is written by Joshua Lederberg.
STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES
TLDR
Evidence is presented that the chemically induced alterations in cellular structure and function are predictable, type-specific, and transmissible in series.
VARIATION IN THE GROUP-SPECIFIC CARBOHYDRATE OF GROUP A STREPTOCOCCI
The phenomenon of apparent loss of group-specific carbohydrate in the course of mouse passage of group A streptococci has been subjected to further study, and several additional variants showing this
STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES
It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance
Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens
TLDR
The present experiments show that specific antibodies directed to either polysaccharide or protein antigens of a single strain can be protective against infection with streptococci containing these antigENS.
Nutritionally variant streptococci from patients with endocarditis: growth parameters in a semisynthetic medium and demonstration of a chromophore
TLDR
The demonstration of a medium which permits adequate growth with a normal ultrastructure of nutritionally variant streptococci will permit the further study of this group of important strePTococci.
Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types
TLDR
Though scientists were initially skeptical that genes [8] were made of DNA, they later recognized that the data reported in “Transformation” were clear evidence that DNA was genetic material, a revelation that furthered research about how organisms grow, develop, and pass on traits to offspring.
PURIFICATION AND PROPERTIES OF DESOXYRIBONUCLEASE ISOLATED FROM BEEF PANCREAS
  • M. Mccarty
  • Biology, Chemistry
    The Journal of general physiology
  • 20 January 1946
TLDR
The enzyme requires activation by magnesium or manganese ion, and citrate serves as a potent inhibitor of the magnesium-activated enzyme, and its enzymatic activity is inhibited by the specific antibody present in the serum of rabbits immunized with enzyme protein.
THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA
  • M. Mccarty
  • Biology, Medicine
    The Journal of experimental medicine
  • 30 November 1949
TLDR
The pattern of antibody response to desoxyribonuclease has been compared to that of streptokinase and streptolysin O in a group of ninety patients from an epidemic of scarlet fever.
THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS
  • M. Mccarty
  • Biology
    The Journal of experimental medicine
  • 30 November 1952
TLDR
The results of fractionation experiments show that the potent proetolytic enzyme of Streptomyces albus is not able to lyse group A streptococci, and that the initiation of lysis is dependent upon the action of a second, non-proteolytic enzymes.
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