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Next-generation genotype imputation service and methods

TLDR
Improvements to imputation machinery are described that reduce computational requirements by more than an order of magnitude with no loss of accuracy in comparison to standard imputation tools.
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Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum.

TLDR
A hierarchical biometric model is presented of the origins of comorbidity among substance dependence, antisocial behavior, and a disinhibited personality style, and it is offered as a novel target for future research to reconcile evidence for general and specific causal factors within the externalizing spectrum.
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Genome-wide association study identifies 74 loci associated with educational attainment

TLDR
Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

TLDR
Evidence is reported for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission, which provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures.
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GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

TLDR
Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.
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Familial studies of intelligence: a review.

A summary of 111 studies identified in a survey of the world literature on familial resemblances in measured intelligence reveals a profile of average correlations consistent with a polygenic mode of…
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Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse.

TLDR
Hyperactivity/impulsivity predicts later substance problems, even after growth in later-emerging CD is considered, whereas inattention alone poses less risk.
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Genetic and environmental influences on human psychological differences.

TLDR
It is concluded that there is now strong evidence that virtually all individual psychological differences, when reliably measured, are moderately to substantially heritable.
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The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

TLDR
The nature of genetic influences on longevity is probably non-additive and environmental influences non-shared, and there is no evidence for an impact of shared (family) environment.
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Childhood externalizing and internalizing psychopathology in the prediction of early substance use.

TLDR
The results suggest that externalizing psychopathology is a robust prospective predictor of a variety of early onset substance use behaviors and is systematically related to degree of substance use involvement.
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