MR1 presents microbial vitamin B metabolites to MAIT cells
- L. Kjer-Nielsen, O. Patel, J. McCluskey
- BiologyNature
- 29 November 2012
It is shown that metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance, and data suggest that MAIT cells use these metabolites to detect microbial infection.
The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes.
- M. McConville, M. Ferguson
- BiologyBiochemical Journal
- 1 September 1993
The structure, function, biosynthesis and role of these major cell surface glycoconjugates in parasite survival and infectivity are discussed, together with some speculations on the evolutionary aspects of the GPI-family.
MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll‐like receptor 2 signaling
- M. D. de Veer, J. Curtis, L. Schofield
- BiologyEuropean Journal of Immunology
- 1 October 2003
It is observed that mice lacking the Toll‐like receptor (TLR) pathway adaptor protein MyD88 were more susceptible to infection with Leishmania major than wild‐type C57BL/6 mice, demonstrating a central role for this innate immune recognition pathway in control of infection, and suggesting that L. major possesses a ligand for TLR.
PimE Is a Polyprenol-phosphate-mannose-dependent Mannosyltransferase That Transfers the Fifth Mannose of Phosphatidylinositol Mannoside in Mycobacteria*
- Y. Morita, C. Sena, T. Kinoshita
- Biology, ChemistryJournal of Biological Chemistry
- 1 September 2006
PimE represents the first PPM-dependent mannosyl-transferase shown to be involved in PIM biosynthesis, where it mediates the fifth mannose transfer.
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
- A. Thorburn, Craig I. McKenzie, C. Mackay
- Biology, MedicineNature Communications
- 23 June 2015
It is shown that high intake of dietary fibre by pregnant mice increases resistance of their progeny to the development of allergic airways disease, and may represent an approach to prevent asthma, including during pregnancy.
Secretory Pathway of Trypanosomatid Parasites
- M. McConville, K. A. Mullin, S. C. Ilgoutz, R. Teasdale
- BiologyMicrobiology and Molecular Biology Reviews
- 1 March 2002
An overview of the organization of the trypanosomatid secretory pathway and connections that exist with endocytic organelles and multiple lytic and storage vacuoles is provided and a number of the molecular components that are required for vesicular transport have been identified.
Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum*
- P. Sanders, P. Gilson, B. Crabb
- BiologyJournal of Biological Chemistry
- 2 December 2005
The proteome of gradient-purified detergent-resistant membranes of mature blood-stage parasites are greatly enriched in GPI-anchored proteins and their putative interacting partners, providing new opportunities for understanding both erythrocyte invasion and anti-parasite immunity.
Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host.
- Thomas Naderer, J. Vince, M. McConville
- BiologyCurrent molecular medicine
- 31 August 2004
These studies suggest that, 1) the major surface glycocalyx components of the promastigote stage (i.e. LPG, GPI-anchored proteins) only have a transient or minor role in macrophage invasion, and that there is considerable functional redundancy in the surface glycocalypsex and/or loss of some components can be compensated for by the acquisition of equivalent host glycolipids.
Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum
- J. MacRae, M. Dixon, M. McConville
- BiologyBMC Biology
- 13 June 2013
The metabolomics approach has allowed us to revise current models of P. falciparum carbon metabolism and found that both asexual and sexual blood stages utilize a conventional TCA cycle to catabolize glucose and glutamine.
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