Frailty in older adults: evidence for a phenotype.
- L. Fried, C. Tangen, M. McBurnie
- MedicineThe journals of gerontology. Series A, Biological…
- 1 March 2001
This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study
- A. Buist, M. McBurnie, E. Nizankowska-Mogilnicka
- MedicineThe Lancet
- 1 September 2007
The 6‐min Walk Test: A Quick Measure of Functional Status in Elderly Adults.
- P. Enright, M. McBurnie, A. Newman
- MedicineChest
- 1 February 2003
The 6MWD test may be used clinically to measure the impact of multiple comorbidities, including cardiovascular disease, lung disease, arthritis, diabetes, and cognitive dysfunction and depression, on exercise capacity and endurance in older adults.
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study.
- J. Walston, M. McBurnie, L. Fried
- MedicineArchives of Internal Medicine
- 11 November 2002
The hypothesis that there is a specific physiological basis to the geriatric syndrome of frailty that is characterized in part by increased inflammation and elevated markers of blood clotting is supported and that these physiological differences persist when those with diabetes and cardiovascular disease are excluded.
Associations of subclinical cardiovascular disease with frailty.
- A. Newman, J. Gottdiener, L. Fried
- MedicineThe journals of gerontology. Series A, Biological…
- 1 March 2001
Cardiovascular disease was associated with an increased likelihood of frail health and infarct-like lesions in the brain on magnet resonance imaging were related to frailty as well.
Public-access defibrillation and survival after out-of-hospital cardiac arrest.
- A. Hallstrom, J. Ornato, M. Proschan
- MedicineNew England Journal of Medicine
- 12 August 2004
Training and equipping volunteers to attempt early defibrillation within a structured response system can increase the number of survivors to hospital discharge after out-of-hospital cardiac arrest in public locations.
Effects of PREMIER Lifestyle Modifications on Participants With and Without the Metabolic Syndrome
- L. Lien, Ann J. Brown, L. Svetkey
- MedicineHYPERTENSION
- 1 October 2007
The data suggest that strategies for lowering BP in individuals with metabolic syndrome may be enhanced by recommendations to adopt the DASH dietary pattern, and diastolic blood pressure, lipids, and homeostasis model assessment responded similarly to both interventions regardless of metabolic syndrome status.
Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia.
- W. Kop, J. Gottdiener, R. Tracy
- MedicineAmerican Journal of Cardiology
- 1 February 2002
Brachial Flow-Mediated Vasodilator Responses in Population-Based Research: Methods, Reproducibility and Effects of Age, Gender and Baseline Diameter
- D. Herrington, L. Fan, M. Espeland
- MedicineJournal of Cardiovascular Risk
- 1 October 2001
Automated analysis of brachial flow-mediated vasodilator responses is both feasible and reproducible in large-scale clinical and population-based research.
Efficacy of aerosolized tobramycin in patients with cystic fibrosis.
- B. Ramsey, H. Dorkin, M. McBurnie
- MedicineNew England Journal of Medicine
- 17 June 1993
The short-term aerosol administration of a high dose of tobramycin in patients with clinically stable cystic fibrosis is an efficacious and safe treatment for endobronchial infection with P. aeruginosa.
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