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Nickel differentially affects NMDA receptor channels in developing cultured rat neurons
Nickel (Ni(2+)) is a transition metal that exerts multiple and complex effects on N-methyl-d-aspartate (NMDA) channels. In both HEK293 cells and Xenopus laevis oocytes expressing recombinant NMDAExpand
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Lead inhibition of NMDA channels in native and recombinant receptors
NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycineExpand
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Multiple pathways of Pb2+ permeation in rat cerebellar granule neurones
The pathways of lead (Pb2+) uptake were studied in fura‐2‐loaded cerebellar granule cells from 8‐day‐old rats. In a nominal Ca‐free external bath, Pb2+ (5–50 µm) determined an increase of theExpand
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The Voltage Sensor Of Cnga1 Channels Becomes Functional When The Hydrophobic Bond Between Phe380 And Leu356 Is Impaired
The super-family of voltage gated ionic channels comprises usual voltage-dependent Na+, K+ and Ca2+ channels, but also cyclic nucleotide gated (CNG) channels which are not voltage dependent. VoltageExpand