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The phototransduction machinery in the rod outer segment has a strong efficacy gradient
Significance Phototransduction is now considered to be a quite thoroughly understood phenomenon. It is well known that new discs are continuously generated at the base of the outer segments (OSs) andExpand
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Nickel differentially affects NMDA receptor channels in developing cultured rat neurons
Nickel (Ni(2+)) is a transition metal that exerts multiple and complex effects on N-methyl-d-aspartate (NMDA) channels. In both HEK293 cells and Xenopus laevis oocytes expressing recombinant NMDAExpand
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Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy
Cyclic nucleotide-gated (CNG) channels are activated by binding of cyclic nucleotides. Although structural studies have identified the channel pore and selectivity filter, conformation changesExpand
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A comparison of electrophysiological properties of the CNGA1, CNGA1tandem and CNGA1cys-free Channels
Three constructs are used for the analysis of biophysical properties of CNGA1 channels: the WT CNGA1 channel, a CNGA1 channel where all endogenous cysteines were removed (CNGA1cys-free) and aExpand
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The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating
The pore region of cyclic nucleotide–gated (CNG) channels acts as the channel gate. Therefore, events occurring in the cyclic nucleotide–binding (CNB) domain must be coupled to the movements of theExpand
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The gating mechanism in cyclic nucleotide-gated ion channels
Cyclic nucleotide-gated (CNG) channels mediate transduction in several sensory neurons. These channels use the free energy of CNs’ binding to open the pore, a process referred to as gating. CNGExpand
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Gating of cyclic nucleotide-gated channels is voltage dependent.
Cyclic nucleotide-gated channels belong to the family of voltage-gated ion channels, but pore opening requires the presence of intracellular cyclic nucleotides. In the presence of a saturatingExpand
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New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods
By combining atomic force microscopy (AFM) imaging and single-molecule force spectroscopy (SMFS), we analyzed membrane proteins of the rod outer segments (OS). With this combined approach we wereExpand
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Lead inhibition of NMDA channels in native and recombinant receptors
NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycineExpand
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Multiple pathways of Pb2+ permeation in rat cerebellar granule neurones
The pathways of lead (Pb2+) uptake were studied in fura‐2‐loaded cerebellar granule cells from 8‐day‐old rats. In a nominal Ca‐free external bath, Pb2+ (5–50 µm) determined an increase of theExpand
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