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Role of oxygen radicals in DNA damage and cancer incidence
TLDR
The epidemiological trials together with in vitro experiments suggest that the optimal approach is to reduce endogenous and exogenous sources of oxidative stress, rather than increase intake of anti-oxidants.
High-Affinity Binding Site for Copper(II) in Human and Dog Serum Albumins (an EPR Study)
TLDR
Detailed analysis of S-band and X-band EPR and optical spectra of [Cu(II)−HSA] revealed that copper forms a complex with HSA involving α-NH2 terminal, two deprotonated peptide nitrogens, and the imidazole nitrogen of His3 in a square planar arrangement.
Role of Radicals and Singlet Oxygen in Photoactivated DNA Cleavage by the Anticancer Drug Camptothecin: An Electron Paramagnetic Resonance Study
Camptothecin (CPT) is an anticancer drug that inhibits topoisomerase I (Topo I), an enzyme closely linked to cell division, by forming a ternary DNA−CPT−Topo I complex. However, it has been shown
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