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Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
TLDR
Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain.
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Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
TLDR
Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential…
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Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET.
TLDR
Unlike capsaicin-induced pain, allodynia was characterized by bilateral activation of inferior prefrontal cortex, suggesting that prefrontal responses to pain are context dependent.
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Development and initial validation of an expanded and revised version of the Short-form McGill Pain Questionnaire (SF-MPQ-2)
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Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
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Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
TLDR
Desipramine relieves pain caused by diabetic neuropathy with efficacy similar to that of amitriptyline, offering an alternative for patients unable to tolerate the latter and blockade of norepinephrine reuptake is likely to mediate the analgesic effect of these antidepressant drugs in diabetic Neuropathy.
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Effects of Desipramine, Amitriptyline and Fluoxetine on Pain in Diabetic Neuropathy
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Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
TLDR
The KCNS1 allele rs734784, involved in neuronal excitability, is presented as one of the first prognostic indicators of chronic pain risk and could help define those individuals prone to a transition to persistent pain, and thus requiring therapeutic strategies or lifestyle changes that minimize nerve injury.
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Influence of Psychological Factors on Risk of Temporomandibular Disorders
TLDR
Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05), but the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype.
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