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β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease
Abstract Recent findings link altered processing of β-amyloid precursor protein (βAPP) to disruption of neuronal Ca 2+ homeostasis and an excitotoxic mechanism of cell death in Alzheimer's disease. AExpand
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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptiveExpand
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Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases
ABSTRACT: Synaptic degeneration and death of nerve cells are defining features of Alzheimer's disease (AD) and Parkinson's disease (PD), the two most prevalent age‐related neurodegenerativeExpand
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Hormesis : a revolution in biology, toxicology and medicine
Hormesis: What it is and Why it Matters.- Hormesis: Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response.- The Fundamental Role of Hormesis in Evolution.-Expand
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Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease.
Endoplasmic reticulum (ER) appears to be a focal point for alterations that result in neuronal dysfunction and death in Alzheimer's disease (AD). Aberrant proteolytic processing and/or trafficking ofExpand
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Activation of TRPML1 Clears Intraneuronal Aβ in Preclinical Models of HIV Infection
Antiretroviral therapy extends the lifespan of human immunodeficiency virus (HIV)-infected patients, but many survivors develop premature impairments in cognition. These residual cognitiveExpand
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Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; Arozena, AA; Adachi, H; Adams, CM; Adams, PD; Adeli, K; Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello,Expand
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Hormesis: What it is and Why it Matters
Hormesis describes any process in which a cell, organism, or group of organisms exhibits a biphasic response to exposure to increasing amounts of a substance or condition (e.g., chemical, sensoryExpand
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A High Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Morten Scheibye-Knudsen1, Sarah J. Mitchell2,3, Evandro F. Fang1, Teruaki Iyama1, Theresa Ward2, James Wang1, Christopher A. Dunn1, Nagendra Singh4, Sebastian Veith5, M. Mahdi Hasan6, AswinExpand
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Therapeutic potential of nanoceria in regenerative medicine
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