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Morphine and oxycodone in the management of cancer pain: plasma levels determined by chemical and radioreceptor assays.
- E. Kalso, A. Vainio, M. Mattila, P. Rosenberg, T. Seppälä
- Chemistry, Medicine
- Pharmacology & toxicology
- 1 October 1990
Results from RRA indicate that oxycodone in vivo is a potent mu-agonist and that at least part of its analgesic action is mediated by active metabolites, thus suggesting their complex interactions in vivo. Expand
Opioid peptides derived from in-vitro proteolysis of bovine whey proteins
Abstract The formation of opioid peptides by in-vitro proteolysis of whey proteins was investigated. Bovine β-lactoglobulin (β-LG) or α-lactalbumin (α-LA) were predigested with pepsin and… Expand
Actions and interactions with alcohol of drugs on psychomotor skills: comparison of diazepam and gamma-hydroxybutyric acid.
- M. Mattila, E. Palva, T. Seppälä, R. Ostrovskaya
- Archives internationales de pharmacodynamie et de…
- 1 August 1978
It is concluded that in the recommended anxiolytic doses used GOBA neither deteriorates driving skills nor importantly increases the effects of low doses of alcohol. Expand
Coffee and caffeine and alcohol effects on psychomotor function
- E. Nuotto, M. Mattila, T. Seppälä, K. Konno
- Clinical pharmacology and therapeutics
- 1 January 1982
It is concluded that coffee does not counteract alcohol inebriation, and caffeinated and decaffeinated coffee also failed to modify alcohol effects. Expand
Anxiogenic effect of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam.
It is suggested that these effects of YOH are mediated not only via adrenergic alpha 2-receptors but also through other mechanisms made important contributions. Expand
Effects of Alcohol, Zolpidem, and Some Other Sedatives and Hypnotics on Human Performance and Memory
- M. Mattila, J. Vanakoski, H. Kalska, T. Seppälä
- Medicine, Psychology
- Pharmacology Biochemistry and Behavior
- 1 April 1998
It is possible that 15 mg Zol impairs memory relatively less than 15 mg Dz does, and that all active agents tended to impair learning and memory, their decremental effects, in declining order, being Zol, Dz > EOH, Ox > Zop. Expand
Variations among non-sedating antihistamines: are there real differences?
It is wise to restrict or avoid using antihistamines (astemizole, terfenadine) that can cause cardiac dysrhythmias, because even severe cardiotoxicity can occur in certain pharmacokinetic drug-drug interactions. Expand
Acute dapsone intoxication: a case with prolonged symptoms.
This result supports the concept of the enterohepatic cycle of dapsone and recommends the use of activated charcoal for several days in acute poisonings caused by DDS. Expand
Diazepam effects on the performance of healthy subjects are not enhanced by treatment with the antihistamine ebastine.
Ebastine did not affect performance objectively or subjectively, yet borderline drowsiness was recorded during the first 3 h, and DZ produced impaired performance in various objective tests, and drowsness, weakness, clumsiness, mental slowness and poor performance were reported on visual analogue scales. Expand
Psychomotor performance of patients with rheumatoid arthritis: cross-over comparison of dextropropoxyphene, dextropropoxyphene plus amitriptyline, indomethacin, and placebo.
- U. Saarialho-Kere, H. Julkunen, M. Mattila, T. Seppälä
- Pharmacology & toxicology
- 1 October 1988
It is concluded that therapeutic doses ofDXP and IN are relatively safe in regard to driving skills and small doses of AMI may not enhance the mild psychomotor effects of DXP. Expand