Share This Author
Morphine and oxycodone in the management of cancer pain: plasma levels determined by chemical and radioreceptor assays.
- E. Kalso, A. Vainio, M. Mattila, P. Rosenberg, T. Seppälä
- Biology, MedicinePharmacology & toxicology
- 1 October 1990
Results from RRA indicate that oxycodone in vivo is a potent mu-agonist and that at least part of its analgesic action is mediated by active metabolites, thus suggesting their complex interactions in vivo.
Opioid peptides derived from in-vitro proteolysis of bovine whey proteins
Coffee and caffeine and alcohol effects on psychomotor function
- E. Nuotto, M. Mattila, T. Seppälä, K. Konno
- MedicineClinical pharmacology and therapeutics
- 1 January 1982
It is concluded that coffee does not counteract alcohol inebriation, and caffeinated and decaffeinated coffee also failed to modify alcohol effects.
Effects of Alcohol, Zolpidem, and Some Other Sedatives and Hypnotics on Human Performance and Memory
Actions and interactions with alcohol of drugs on psychomotor skills: comparison of diazepam and gamma-hydroxybutyric acid.
- M. Mattila, E. Palva, T. Seppälä, R. Ostrovskaya
- Medicine, PsychologyArchives internationales de pharmacodynamie et de…
- 1 August 1978
It is concluded that in the recommended anxiolytic doses used GOBA neither deteriorates driving skills nor importantly increases the effects of low doses of alcohol.
Pharmacokinetics of Oxicam Nonsteroidal Anti-Inflammatory Agents
Although the development of sudoxicam was stopped because of frequent adverse effects, this drug is interesting because, unlike other oxicams, its appears to have nonlinear elimination pharmacokinetics.
Anxiogenic effect of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam.
- M. Mattila, T. Seppala, M. Mattila
- Medicine, BiologyInternational clinical psychopharmacology
- 1 July 1988
It is suggested that these effects of YOH are mediated not only via adrenergic alpha 2-receptors but also through other mechanisms made important contributions.
Variations among non-sedating antihistamines: are there real differences?
It is wise to restrict or avoid using antihistamines (astemizole, terfenadine) that can cause cardiac dysrhythmias, because even severe cardiotoxicity can occur in certain pharmacokinetic drug-drug interactions.
Acute dapsone intoxication: a case with prolonged symptoms.
This result supports the concept of the enterohepatic cycle of dapsone and recommends the use of activated charcoal for several days in acute poisonings caused by DDS.
Diazepam effects on the performance of healthy subjects are not enhanced by treatment with the antihistamine ebastine.
Ebastine did not affect performance objectively or subjectively, yet borderline drowsiness was recorded during the first 3 h, and DZ produced impaired performance in various objective tests, and drowsness, weakness, clumsiness, mental slowness and poor performance were reported on visual analogue scales.