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DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.
The Cdc25C phosphatase mediates cellular entry into mitosis. The cdc25C gene is a target for transcriptional downregulation by the tumor suppressor protein p53, and this repression can be shown toExpand
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The C-terminus of p53 binds the N-terminal domain of MDM2
The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former's N-terminal region and core domain, yet the extreme p53 C-terminal region contains lysine residues ubiquitinated byExpand
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p53 linear diffusion along DNA requires its C terminus.
In cells, sequence-specific transcription factors must search through an entire genome to find their target sites in promoters. Such sites may be identified by using one-dimensional (linearExpand
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Specific expression of soluble adenylyl cyclase in male germ cells.
The cAMP signaling pathway is an important mediator of extracellular signals in organisms from prokaryotes to higher eukaryotes. In mammals two types of adenylyl cyclase synthesize cAMP; a ubiquitousExpand
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A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.
We reported previously that when cells are arrested in S phase, a subset of p53 target genes fails to be strongly induced despite the presence of high levels of p53. When DNA replication isExpand
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p53-Dependent p21 mRNA Elongation Is Impaired when DNA Replication Is Stalled
ABSTRACT We have previously reported that when DNA replication is blocked in some human cell lines, p53 is impaired in its ability to induce a subset of its key target genes, including p21WAF1/CIP1.Expand
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Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus
The p53 tumor suppressor is a nucleocytoplasmic shuttling protein that is found predominantly in the nucleus of cells. In addition to mutation, abnormal p53 cellular localization is one of theExpand
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The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.
DNA binding by numerous transcription factors including the p53 tumor suppressor protein constitutes a vital early step in transcriptional activation. While the role of the central core DNA bindingExpand
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Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein
Both sequence-specific DNA binding and exonuclease activities have been mapped to the central conserved core domain of p53. To gain more information about these two activities a series of mutantsExpand
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