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An expanded definition of the adult respiratory distress syndrome.
- J. Murray, M. Matthay, J. Luce, M. R. Flick
- MedicineThe American review of respiratory disease
- 1 September 1988
An expanded definition of ARDS is proposed that takes into account new knowledge about adult respiratory distress syndrome and its clinical features, physiologic disturbances, prognosis, and pathologic findings.
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.
- R. Brower, M. Matthay, A. Morris, D. Schoenfeld, B. Thompson, A. Wheeler
- MedicineThe New England journal of medicine
- 4 May 2000
In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
The acute respiratory distress syndrome: pathogenesis and treatment.
There is no effective pharmacologic therapy, although cell-based therapy and other therapies currently being tested in clinical trials may provide novel treatments for ARDS.
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.
This list of features and measurements of ALI is intended as a guide for investigators, and ultimately investigators should choose the particular measurements that best suit the experimental questions being addressed as well as take into consideration any unique aspects of the experimental design.
Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.
In patients with acute lung injury and ARDS who receive mechanical ventilation with a tidal-volume goal of 6 ml per kilogram of predicted body weight and an end-inspiratory plateau-pressure limit of 30 cm of water, clinical outcomes are similar whether lower or higher PEEP levels are used.
Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice1
- N. Gupta, X. Su, B. Popov, J. W. Lee, V. Serikov, M. Matthay
- Biology, MedicineThe Journal of Immunology
- 1 August 2007
Treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice.
Lung epithelial fluid transport and the resolution of pulmonary edema.
There is convincing evidence that active sodium and chloride transporters are expressed in the distal lung epithelium and are responsible for the ability of the lung to remove alveolar fluid at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema.
Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway?
- K. Brohi, M. Cohen, M. Ganter, M. Matthay, R. Mackersie, J. Pittet
- Medicine, BiologyAnnals of surgery
- 1 May 2007
Early traumatic coagulopathy occurs only in the presence of tissue hypoperfusion and appears to occur without significant consumption of coagulation factors, which is consistent with activated protein C activation and systemic anticoagulation.
The acute respiratory distress syndrome.
An overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome is provided and advances in the areas of pathogenesis, resolution, and treatment are discussed.