• Publications
  • Influence
An expanded definition of the adult respiratory distress syndrome.
More than twenty years ago, Ashbaugh and coworkers, (1), in a now classic article, described. 12 patients whose striking but uniform clinical, physiologic, roentgenographic,and pathologicExpand
  • 2,268
  • 139
The acute respiratory distress syndrome.
  • 1,440
  • 139
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.
BACKGROUND Traditional approaches to mechanical ventilation use tidal volumes of 10 to 15 ml per kilogram of body weight and may cause stretch-induced lung injury in patients with acute lung injuryExpand
  • 9,646
  • 82
  • PDF
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
Transforming growth factor beta (TGF beta) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGF beta geneExpand
  • 1,645
  • 76
The acute respiratory distress syndrome: pathogenesis and treatment.
The acute respiratory distress syndrome (ARDS) causes 40% mortality in approximately 200,000 critically ill patients annually in the United States. ARDS is caused by protein-rich pulmonary edema thatExpand
  • 638
  • 60
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.
Acute lung injury (ALI) is well defined in humans, but there is no agreement as to the main features of acute lung injury in animal models. A Committee was organized to determine the main featuresExpand
  • 810
  • 55
  • PDF
Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.
BACKGROUND Most patients requiring mechanical ventilation for acute lung injury and the acute respiratory distress syndrome (ARDS) receive positive end-expiratory pressure (PEEP) of 5 to 12 cm ofExpand
  • 1,824
  • 52
  • PDF
Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice1
Recent in vivo and in vitro work suggests that mesenchymal stem cells (MSC) have anti-inflammatory properties. In this study, we tested the effect of administering MSC directly into the airspaces ofExpand
  • 780
  • 47
Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway?
Objectives:Coagulopathy following major trauma is conventionally attributed to activation and consumption of coagulation factors. Recent studies have identified an acute coagulopathy present onExpand
  • 677
  • 38
  • PDF
Lung epithelial fluid transport and the resolution of pulmonary edema.
The discovery of mechanisms that regulate salt and water transport by the alveolar and distal airway epithelium of the lung has generated new insights into the regulation of lung fluid balance underExpand
  • 613
  • 37
  • PDF