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Three-dimensional human tissue chips fabricated by rapid and automatic inkjet cell printing.
Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly(gamma-glutamic acid)-sulfonate matrix for tissue engineering.
The acidic pH-sensitive controlled release of fibroblast growth factor-2 from a biodegradable hydrogel without any denaturation of the FGF-2 was successfully performed by a combination of F GF-2 activity and acidic pH, and may be useful for tissue engineering fields such as neovascular treatment for ischemia and inflammation. Expand
Three-dimensional cell culture technique and pathophysiology.
- M. Matsusaki, C. Case, M. Akashi
- Computer Science, Medicine
- Advanced drug delivery reviews
- 30 July 2014
A brief overview on current 3D-tissue fabrication technologies and their biomedical applications is provided and it is shown that physiological human tissue responses can be replicated in the nano/micro-meter ranges. Expand
Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity.
- Gianpiero Lazzari, V. Nicolas, M. Matsusaki, M. Akashi, P. Couvreur, S. Mura
- Chemistry, Medicine
- Acta biomaterialia
- 15 September 2018
This new 3D triple co-culture model closely mimicked the resistance to treatments observed in vivo, resulting in a reduction of cancer cell sensitivity to the anticancer treatment. Expand
Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays.
- Y. Amano, A. Nishiguchi, +6 authors M. Akashi
- Materials Science, Medicine
- Acta biomaterialia
- 15 March 2016
Construction of vascularized 3D-iPSC-CM tissues by a newly-discovered filtration-Layer-by-Layer (LbL) technique is reported, finding that the introduction of normal human cardiac fibroblasts into the iPSC -CM tissues modulated organization and synchronous beating depending on NHCF ratios. Expand
Effects of angiogenic factors and 3D-microenvironments on vascularization within sandwich cultures.
- A. Nishiguchi, M. Matsusaki, Yoshiya Asano, H. Shimoda, M. Akashi
- Biology, Medicine
- 1 June 2014
3D-microenvironments controlled at the single layer level showed that sandwich culture between more than 3 fibroblast-layers induced tubule formation, and it was found that not only angiogenic factors, but also the 3D- microenvironments of the endothelial cells played crucial roles in tubules formation in vitro. Expand
Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells
- Maki Takeda, S. Miyagawa, +10 authors Y. Sawa
- Chemistry, Biology
- Tissue engineering. Part C, Methods
- 1 October 2017
The 3D-hiPSC-CT exhibited doxorubicin-sensitive cytotoxicity and hERG channel blocker/isoproterenol-sensitive electrical activity in vitro, indicating its usefulness for drug-induced cardiotoxicity assays or drug screening systems for drug discovery. Expand
The construction of 3D-engineered tissues composed of cells and extracellular matrices by hydrogel template approach.
3D-engineered tissues constructed by the hydrogel template approach may be useful as a new class of soft-tissue engineering technology to substitute a synthetic polymer scaffold to the ECM scaffold produced from the cultured cells. Expand
Preparation of Biodegradable Hollow Nanocapsules by Silica Template Method
Biodegradable hollow nanocapsules were successfully prepared by a combination of layer-by-layer assembly and the silica template method. Ultrathin polymer films were constructed on the surface of t...
Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging
Summary Elastic fibers are present in a variety of tissues and are responsible for their resilience. Until now, no optical contrast agent in the near-infrared (NIR) wavelength range of 700–900 nm has… Expand